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Prototype Drugs
Protoype Drugs in UAA Nursing 180
Prototype Drug | Theraputic Class | Pharmacologic Class | Action | Uses | Admin | Contraindications | Interactions | Overdose |
---|---|---|---|---|---|---|---|---|
Prazosin (Minipress) | Antihypertensive | Adrenergic-Blocking Drug | Selective alpha1- adrenergic anagonist that competes with norepinephrine | rapid decrease in peripheral resistance to reduce blood pressure | Give a low dose to avoid severe hypotension; preg C | Safety during pregnancy and lactation is not established | Use of lower antihypertensives and diuretics produces synergistic effect; increases urinary metabolites of VMA and norepinephrine (adrenal tumor); no saw palmetto and nettle root | May cause hypotension; to fix tx with fluid expanders and vasopressors(dopamine/dobutamin) |
bethanechol (Duvoid, Urecholine) | Nonobstructive urinary retention agent | Muscarinic cholinergic receptor agent | direct acting Para-ympathomimetic that cuases typical parasympathetic action | increases smooth muscle tone and contractions'; nonobstructive urinary rention | Never IM/IV; Oral and sub q are not interchangeable; Monitor blood pressure, pulse and resp before admin and at least 1 hour after sub-q admin; Preg C | Pt with asthma, epilepsy, parkinsonism and preg/laction safety has not been established | cholinesterase inhibitors, procainamide, quinidine, atropine, and epinephrine; may increase lab of AST, amylase, and lipase; no angel's trumpet, jimson weed, or scopalia | Treatment of overdose is atropine sulfate Sub-Q, than IV for emergencies |
Physostigmine (Antilirum) | Antidote for Atropine-induced delirium | acetylcholinersterase inhibitors | ||||||
phenylephrine (Neo-Synephrien) | Nasal decongestant; mydriatic drug; antihypotensive | Adrenergic agent | Sympathetic stimulation | Reduces nasal congestion; dilate the pupil; reverse acute hypotension and vascular shock | Paraenteral admin can cuase tissue injury with extravasation; ophthalmic drops may damage soft contact lenses; preg C | Do not give to pt with acute pancreatitis; heart disease, hepatitis, or narrow-angle glaucoma | MAO inhibitors, tricyclic antidepressants, ergot alkaloids, oxytocin, alpha blockers and beta blockers, digoxin, iron salts, | May cause tachycardia and hypertension; tx with alpha blocker such as phentolamine (regitine) may reduce blood pressure |