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Pharm Exam 3


NSAIDs Inhibits COX enzyme, blocks prostaglandins; can cause severe GI and renal toxicity
Methotrexate Inhibits cyytokines and purine biosynthesis, stimulates adenosine; teratogenesis, thrombocytopenia, elevated LFTs
Hydroxychloroquine Retinopathy (Amsler grid)
Azathioprine suppresses B and T cells via 6 thioguanine; bone marrw suppresion, increased incidence of infections
Cyclophosphamide works via active metabolite
Cyclosporine inhibits interleukin 1 and 2; can cause significant nephrotoxicity, HTN, hyperkalemia, hepatotoxicity, gingival hyperplasia, hirsutism
Leflunomide MC side effect: diarrhea; most significant: hepatotoxicity, immunosuppression, hematologic toxicity, teratogenic
MMF Semisynthetic, mycophenolic acid; causes hematologic and hepatotoxicity
Sulfasalazine prodrug cleaved by bacteria in the colon; can cause GI symptoms and a rash; interacts with antibiotics, iron supplements, and warfarin
Abatacept Binds to APC on the T cell; can cause "flu-like symptoms"
Rutiximab monoclonal antibody that suppresses B cells; Best to give with MTX
Tocilizumab IL-6 mediated; can cause URI, neutropenia, thrombocytopenia, increased risk for infections; CYP450 inducer
Adalimumab TNF-blocking agent; can cause a local injection site reaction
Certolizumab Pegol TNF-blocking agent; polyethylene glycol; used for Crohns disease
Etanercept TNF blocking agent
Golimumab TNF blocking agent; treatment of psoriatic arthritis and ankylosing spondylitis
Infliximab TNF blocking agent,given IV
Prednisone and Methylprednisolone Anti--inflammatory, analgesic, immunosuppressive; can cause adrenal suppression, Cushing's, osteoporosis, gastritis, glucose intolerance
Colchicine Anti-inflammatory; can cause GI side effects and seizures; used as 2nd line for acute gout attacks
Probenecid, Sulfinpyrazone Inhibits reabsorption of uric acid; can cause nephrotic syndrome
Allopurinol, Febuxostat Reduces uric acid production; can cause hepatotoxicity, peripheral neuritis, bone marrow suppression
Pegloticase Converts uric acid to inactive form: allantoin; BBW of hypersensitivity/anaphylactoid reactions
Created by: LexFuturePAC



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