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lee-hypothalamic

QuestionAnswer
Sermorelin GHRH analogue: assess pituitary secretion of GH and GH insufficiency
Protirelin TRH analogue
Corticorelin CRH analogue: differentiating pituitary and ectopic production of ACTH in Cushing Syndrome
Somatostatin GH-IH: inhibits GH, TSH, gastrin, and VIP; inhibits bile flow and GI
Octreotide somatostatin analogue: 45x more potent
Octreotide USE/ADR acromegaly, esophageal varices
GnRH agonists and antagonists agonist (short) = Gonadorelin
Gonadorelin USE pituitary and gonadotropin stimulation in infertility (ovulation failure)
Leuprolide/Ganirelix USE precocious puberty, prostate cancer, breast cancer, endometriosis
ACTH analogue Cosyntropin: congenital adrenal hyperplasia (21,OH), dx. adrenal insufficiency
Adrenal insufficiency Cosyntropin: urine test = if increase cortisol, adrenal gland normal, if no increase in cortisol after cosyntropin admin. = primary adrenal failure
Somatropin GH: released 2,4 rem stages, Ghrelin in fundus
Synthetic GH/IGF-1 and USES Somatropin, Somatrem = Creutzfeldt-Jakob from cadavers
GH insensitive patients Mecasermin (IGF-1)
Pegvisomant (somavert) GH receptor antagonist for acromegaly
Acromegaly Octreotide (somatostain)
Urofillitropin/Fillitropin FSH agonist (stimulate follicle maturation, estrogen synth, spermatogenesis)
Menotropin FSH and LH agonist
hChorionic Gonadotropin LH agonist
Gonadotropin agonist USES ovulation induction, male infertility
Hyperprolectinoma TX Bromocriptine and Cabergoline
Pitocin Oxytocin common prepreation
Oxytocin ADR/Contraindicated ADR = seizures, hypotension, hyponatremia*
Atosiban Oxytocin antagonist = tx. for preterm labor
V2 Renal fluid reabsorption via Vasopression
V1 blood vessel constriction via AVP at high concentrations
Vasopression analogue Desmopressin
Desmopressin actions V2 activation, stimulate vWF and VIII, little effect on bp
Diabetes insipidus tx. Desmopression
Desmopression USE nocturnal enuresis, mild hemophillia, vW disease
Conivaptan Inhibits vasopressin receptor, used in SIADH
SIADH tx. Lithium, Demeclocycline, Conivaptan
Nephrogenic diabetes insipidus tx. Thiazides, Amiloride
Created by: lsilkman
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