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P1 Top 200
Group 4
| Brand | Generic | Indication | Form | Dose | MOA |
|---|---|---|---|---|---|
| Bactroban | Mupirocin | Topical infection | Ointment (nasal), cream | PEDS & ADULT: tid | Inhibition of protein synthesis |
| Cipro | Ciprofloxacin | Sinusitis, prostatitis, bronchitis, bone and joint infections, abdominal infections, diarrhea | Tablet (ER), ear & eye drops, IV, reconstitution | 250 to 750 mg BID; 10 to 20 mg/kg BID | Inhibition of topoisomerase II enzymes |
| Cleocin | Clindamycin | Bacterial vaginosis | Cream (pregnant only), vaginal suppository, IV, lotion, gel, swab, external solution, external foam | 150-450 mg q6h | Binds to 50S preventing bacterial protein synthesis |
| Diflucan | Flucanazole | Candidiasis, meningitis | Tablet, IV, reconstitution | 50 to 400 mg QD; 6 to 12 mg/kg QD | Interferes with P450 activity |
| Flagyl, Metrocream, Metrogel | Metronidazole | Bacterial vaginosis | Tablet (ER), capsule, IV, cream, lotion, gel (external/vaginal) | 0.75% (37.5 mg) intravaginally BID x 5 days; 1.3% (65 mg) intravaginally once | Inhibition of protein synthesis |
| Keflex | Cephalexin | Otitis, bronchitis, bone infections, skin infections, UTI | Tablet, capsule, reconstitution | 250 mg q6h; 25 to 50 mg/kg/day | Inhibits bacterial wall synthesis |
| Levaquin | Levofloxacin | Sinusitis, bronchitis, prostatitis, pyelonephritis, skin infections, plague, anthrax, UTI, pneumonia | Tablet, oral & IV solution, eye drops | 250 to 750 mg/day; 8 mg/kg BID | Inhibition of topoisomerase II enzymes |
| Macrobid | Nitrofurantoin Macrocrystals | UTI | Capsule, suspension | 50 to 100 mg QID; 5 to 7 mg/kg/day | Inhibits protein and bacterial wall synthesis |
| Omnicef | Cefdinir | Sinusitis, otitis, bronchitis, pharyngitis, skin infections, pneumonia | Capsule, reconstitution | 600 mg x 10 days; 14 mg/kg x 10 days | Inhibits bacterial wall synthesis |
| Penicillin VK, Penicillin G | Penicillin VK, G | Fever, sinusistis, pharyngitis, heart disease, venereal infections, strep, staph, pneumonia | Tablet, reconstitution (oral & injection) | VK: 125 to 500 mg q6-8h; G: 1.2 mil u/mo; 50,000 u/kg single dose | Inhibits bacterial wall synthesis |
| Periostat, Vibra-tabs, Doryx, Monodox, Oracea | Doxycycline | Fever, sinusitis, skin & eye inf., sexually transmitted inf., Rickettsial, Vincent, Yaws, & Zoonotic inf., gram-negative inf., actinomycosis, intestinal amebiasis, anthrax, cholera, clostridium, listeriosis, malaria prophylaxis, rosacea | Tablet (DR), capsule (DR), IV, reconstitution, syrup | 100 mg BID | Inhibition of protein synthesis |
| Solodyn, Dynacin, Minocin | Minocycline | Periodontitis | Tablet (ER), capsule, IV | 45 to 200 mg/day; 2 mg/kg BID | Inhibition of protein synthesis |
| Sovaldi | Sofosbuvir | Hepatitis C | Tablet | 400 mg QD | Antiviral prodrug |
| Valtrex | Valacyclovir | Cold sores, herpes, chickenpox | Tablet | 1 to 2 g/day; 20 mg/kg tid x 5 days | Inhibits DNA synthesis and viral replication. |
| Zithromax, ZPAK | Azithromycin | Sinusitis, otitis, pharyngitis, urethritis, cervicitis, skin infections, COPD, CAP, MAC tx, genital ulcer | Tablet, eye drops, packet, reconstitution (IV) | 500 mg/day; 12 mg/kg/day | Binds to 50S preventing bacterial protein synthesis |
| Zovirax | Acyclovir | Herpes, chickenpox | Tablet, capsule, suspension, IV, ointment, cream | 200 to 800 mg BID x 5 to 10 days; 20 mg/kg QID x 5 days | Inhibits DNA synthesis and viral replication. |
| Amoxil, Trimox, Moxatag | Amoxicillin | Skin infections, UTI, ENT infections, LRI, gonorrhea, H. pylori | Tablet (chewable, ER), capsule, reconstitution | 500 mg BID; 25 mg/kg/day | Inhibits bacterial wall synthesis |
| Ancef | Cefazolin | Endocarditis, bronchitis, biliary infection, bone and joint infection, genital infection, UTI, skin infections, perioperative prophylaxis, septicemia | IV reconstitution | 750 mg to 6 g QD | Inhibits bacterial wall synthesis |
| Augmentin | Amoxicillin/Clavulanic Acid | Sinusitis, otitis, bronchitis, skin infections, UTI, pneumonia | Tablet (ER), reconstitution | 500 mg BID; 200 to 400 mg chewable tabs | Beta-lactamase inhibitor |
| Bactrim, Septra | Sulfamethoxazole/Trimethoprim | Bronchitis, otitis, enteritis, UTI, PCP, diarrhea | Tablet, IV, suspension | 800/160 mg BID; 40/8 mg/kg BID | SMX: Inhibition of dihydrofolic acid formation. TMP: Inhibition of dihydrofolic acid reduction. |