Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

exam 3 pharm

ch 24

myasthenia gravis (MG) ☺lack of nerve impulses and muscle responses at myneuronal junction ☻weakness in resp system, facial muscles, and extremities ♥cranial nerve involvement causes ptosis, difficulty chewing and swallowing, respiratory arrest from resp muscle paralysis ♦caused by autoimmune destruction of ACh
MS ☺dx by MRI shows sclerotic plaques ☻s/s of MS: dipolpia, weakness of extremities or spasticity ♥lab tests: ↑IgG in CSF and ↑ratio to albumin in serum
myasthenic crisis ☺triggers: inadequate dosing of AChE inhibitors, infxn, pregnancy, emotional stress, menses, surgery, trauma, hypoK, temperature extremes, etoh intake ☻crisis can occur 3-4 hrs after taking aminoglycoside and fluoroquinolines, calcium channel blockers, dilantin, psychotropics ♥death can result from paralyis of resp muscles
OD with AChE inhibitors ☺may cause cholinergic crisis which is an acute exacerbation of symptoms ☻occurs 30-60 min after taking anticholinergics - due to continuous depolarization of postsynaptic membranes that create neuromuscular blockade s/s: severe muscle weakness, miosis (pupil constriction), pallor, sweating, vertigo, excess salivation, n/v/d, abd cramps, bradycardia, and fasciculations (invol muscles twitching)
neostigmine ☺treats MG ☻short acting AChE inhibitor ♥given q3-4 hr - must give on time
pyridostigmine bromide (mestinon) prototype drug chart ☺immediate action ☻given every 3-6 hrs ♥CI: GI and GU mechanical obstruction, severe renal disease, ileus ♦caution: asthma, HoTN, bradycardia, hyperthyroidism, renal dx, pregnancy and BF ♣used to treat MG, anti-nerve gas agent used to tx Soman, muscle relaxant,
pyridostigmine bromide (mestinon) prototype drug chart continued ☺s/e: n/v/d, HA, blurred vision, dizziness, abd cramps, excess saliva and sweating, rash, miosis ☻a/e: HoTN, bradycardia, dyspnea, bronchospasm, dysrhythmias, seizures
NC pyridostigmine bromide (mestinon) ☺pt should avoid atropine and muscle relaxants ☻assess for s/s of MG crisis ♥effectiveness of tx should be ↑muscle strength ♦rate and depth of resp should be monitored ♣give med IV undiluted at rate of 0.5 mg/min, DO NOT ADD TO IV FLUIDS ♠atropine sulfate is antidote for cholinergic crisis ☺teach: wear medical alert ID ☻take before meals for best absorption
ambenonium (mytelase) ☺long acting ☻given when a pt does not respond to neostigmine or pyridostigmine b/c of bromide component ♥can be taken with glucocorticoids
derophonium (tensilon) ☺used to dx MG, if muscle strength is ↑ immediately or if ptosis is immediately corrected the dx is most likely MG
tx of MS ☺acute attack: fatigue, motor weakness, optic neuritis - glucocorticoids ☻recurrent: spasticity - BRMs, interferon, glatiramer acetate (Copaxone) - antineoplastic, give IV q3mo with accumulative life time dose of no more than 140 mg/m2 ♦fingolimod (gilenya) ♣chronic: progressive s/s such as using wheelchair - immunosuppressant cyclophosphamide (cytoxan)
cyclobenzaprine (flexeril) prototype drug chart ☺muscle relaxant ☻CI: acute MI, av blocks, bundle branch blocks, arrhythmias, HF, hyperthyroidism, paralytic ileus, concurrent use of MAOIs or within 14 days after d/c ♥caution: seizures, etoh, CNS depressants, glaucoma, BPH, urinary retention, liver dx, BF
cyclobenzaprine (flexeril) prototype drug chart continued ☺s/e: anticholinergic effects - blurred vision, constipation, dry mouth, tachycardia, urinary retention, drowsiness, dizziness, HA, fever, abd pain, v/d, flatulence, ED ☻a/e: allergic reaction, angioedema, MI, seizures, ileus
NC cyclobenzaprine (flexeril) ☺determine if spasm is acute or chronic ☻CI in narrow angle glaucoma or MG ♥monitor liver functions - ALP, ALT and GGT ♦report abnormal VS ♣teach: do not stop abruptly, taper over 1 wk to avoid rebound spasms, take no more than for 3 wks, avoid etoh and CNS depressants s/e: n/v, dizziness, fainting, HA, diplopia ♠take with food
diazepam (valium) ☺relieve muscle spasms assoc with paraplegia and CP ☻CI in narrow angle glaucoma
baclofen (lioresal) ☺muscle spasms caused by MS and spinal cord injury ☻OD may cause CNS depression, drowsiness, dizziness, nausea, HoTN
dantrolene sodium (dantrium) ☺for spasms from spinal cord injury, stroke, MS ☻start dose low and ↑q4-7 days, ♥avoid etoh or CNS depressants
arisoprodol (soma) ☺skeletal muscle relaxant ☻has CNS depressant effects ♥avoid etoh or CNS depressants ♦should be used short term only
methocarbamol (robaxin) ☺acute muscle spasms and the tx of tetanus ☻CNS effects ♥avoid etoh or CNS depressants ♦urine may be green, brown, or black
metaxalone (skelaxin) ☺acute muscle spasms ☻can be toxic with mild OD ♥used in combo with asa and caffeine (norgesic)
succinylcholine (anectine) ☺for surgical skeletal muscle relaxation and used for endoscopy and intubation ☻0.3-1.1 mg/kg
Created by: nursingTSJC2013



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards