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pharm final

ch 18

epi can be admin subQ, IV, topically, inhalation, intracardiac it is not given orally because it is rapidly metabolized by the liver and excreted in urine
epi used in emergencies treats anaphylaxis potent inotropic - ↑contractility, promotes vasoconstriction, and CO high doses can result in dysrhythmias - must be on ECG monitor
epi and digoxin dysrhythmia
epi and beta blockers antagonizes the action of epi
epi and MAOIs make epi's effects intensified and prolonged
antedote for extravasation of norepi and dopamine ☺phentolamine mesylate (regitine), 5-10 mg diluted in 10-15 mL of saline infiltrated into area for IV extravasation ☻redness and tissue warmth are signs of effective treatment
atenolol and metropolol ☺selective ☻↓BP and pulse
atenolol (Tenornmin) ☺selective beta blocker ☻CI in bradycardia, heart block, cardiogenic shock, pulm edema, acute bronchospasm, and pregnancy ♥once per day dosing ♦PO: onset 1 hr, peak 2-4 hrs, duration 24
doxazosin (Cardura) alpha1-adrenergic blocker ☺treats HTN and BPH ☻s/e: dizziness, HA, syncope
atenolol (Tenormin) beta1-adrenergic blocker ☺HTN, angina, dysrhythmia ☻check apical pulse ♥do not give if HR <60
atenolol Prototype Drug ☺beta1-adrenergic blocker ☻CI: bradycardia, heart block >1st degree, cardiogenic shock, pulm edema, acute bronchospasm, uncompensated cardiac failure, pregnancy, lactation ♥used to tx angina, HTN, MI, HF, ♣s/e: drowsiness, dizziness, syncope, depression, alopecia, weakness, n/v/d, cool extremities, impotence, ↓libido a/e: bradycarida, HoTN, HF, masking of hypoglycemia, bronchospasm, pulm edema, dysrhythmias, thrombocytopenia
Created by: nursingTSJC2013