Save
Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Mood Stabilizer

Pharmacology

QuestionAnswer
Manic Episodes -elevated, expansive, or irritable for at least 1wk -grandiosity, decrease in need for sleep, more talkative, racing thoughts, distractibility, increased agitation, excessive risk-taking
Hypomanic Episodes for at least 4 days -same symptoms as manic epidodes -no marked impairment/hospitalization/pscyhosis
Mixed State -mix of manic and depressed -depressed: 1 of these: depressed mood, decr. interest/pleasure plus 4 of these: change in weight/appetitem, insomina, agitation, fatique, guilt, decr.ability to think. thougths of death
Drug for bipolar disorder: the mood-stabilizing agents LVCL-Lithium, valproic acid(Depakote; Depakene), carbamazepine (Tegretol), lamotrigine (Lamictal) -not effective alone in major depression -effective against both manic and depressive stages of bipolar -Teratogenic esp. 1st trimester
atypical neuroleptics in bipolar disorder risperidone, ziprasidone, olanzapine, quetiapine, asenpaine, aripirazole
lithium effective initially, but wears off-need a substitution or addition of Rx -predictors of poor response: rapid cycles, family Hx, Hx of drug abuse, mixed state
Acute Treatment with lithium -1-2wk latency -neuropleptic often combined; BZD for first few weeks -0.8-1.5mEq/L (blood level); 2+ mEq/L (toxic) low therapeutic index drug-potential cardiotoxicity
chronic treatment with lithium first agent for maintenance -therapeutic range=0.6-1.2 mEq/L -may need to add neuroleptic, anticonvulsant, or antidepressant -watch for adverse effect -lifetime Rx is prob. required
adverse effect of Li -category D for preg: congential cardiac malformations in 1st trimester -diarrhea, disturbances in fluid homeosasis (edema, thirst, urinary frequency) -decr. in thyroid hormone secretion
acute toxic of Li 2.0mEq/L in young adults 1.5mEq/L in elderly -NV -cardiac arrythmias, conduction deficits -renal failure
adverse drug interactions with Li plasma Li level increase & decrease renal clearance -thiazide diuretics, ACE inhibitors, NSAIDS
Valproic Acid -as effective as lithium for acute mania (alternative to Li) -sodium valproate or divalproex -pregnancy D: neural tube defects -effective in maintenance +/- lithium or neuroleptic
Carbamazepine -acute mania in some lithium non-responders -effective in maintenance +/- lithium or neuropletic -Major Advese: sedation, N/V, pancytopenia -hypersensitivity/ rashes -pregnancy D: cleft lip, palate, facial dysmorphias
Lamotrigine effective alone in bipolar depression but NOT MANIA effective in maintenance (+ lithium)-mainly used for maintenance -slow titration needed - no effect on acute mania -ADVERSE: sedation, Stevens-Johnson (rashes) -pregnancy "C"
mechansims not clear; but they are all sodium blockers, we don't know why other Na blockers don't work
Created by: Eunj
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards