Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Anti-inflammatory Rx

Pegloticase recombinant uricase. Use for actively symptomatic gout.
Pegloticase Used for severe gout where other rate-lowering treatments have failed
Pegloticase Catalyzes the oxidation of uric acid into allantoin
Allopurinol inhibits xanthine oxidase
Allopurinol Treatment for chronic tophaceous gout. Especially with renal insufficiency
Febuxostat Newer xanthine oxidase inhibitor.
Sulfinpryazone effects transport sites in middle segment of proximal tubules responsible for reabsorption of uric acid
Sulfinpyrazone can be used as an anti platelet drug
Probenecid effects transport sites in middle segment of proximal tubules responsible for reabsorption of uric acid
Sulfinpryazone more potent than probenecid
Probenecid Results in increase in penicillin, cephalosporins, sulfoamides, and indomethacin
Probenecid blocked by salicylates
Uricosurics Increase excretion of uric acid. Ex: probenecid and sulfinpyrazone
Colchicine given in first 12-36 hours of gout attack
Colchicine antimitotic
Indomethacin NSAID for acute treatment of gout
Acetaminophen indicated for mild to moderate pain and fever.
Acetaminophen Treat overdose with acetylcysteine
Acetaminophen Weak inhibitor of cycloxygenases in peripheral tissue
TNF-α blocking agents Adalimumab, certolizumab, etanercept, golimumab, infliximab
Multiple drug therapy for rheumatoid arthritis Methotraxte with cyclosporine, chloroquine, hydrochloroquine, leflunomide, inflixmab, adalimumab, rituximab, or etanercept.
Sulfasalazine metabolize to sulfapyridine
Sulfasalazine indicated to rheumatoid arthritis
Rituximab Targets CD20 B lymphocytes and depletes them.
Mycophenolate mofetil (MMF) Inhibits T cell proliferation, inhibits E-selectins and P-selectins
Rituximab indicated for arthritis
Mycophenolate mofetil (MMF) Indicated for renal disease due to systemic lupus erthematosus
Methotrexate Used in 50-70% patients with arthritis
Methotrexate Inhibits neutrophil chemotaxis.
Leflunomide Decrease in ribonucleotide synthesis and arrests cells in G1
Leflunomide Indicated for arthritis
Cyclosporine inhibits IL-1 and IL-2 receptor. Inhibits macrophage-Tcell interaction and T cell responsiveness.
Cyclophosphamide Suppress T and B cell function by 30-40 %
Choroquine and hydrochloroquine Indicated for malaria
Azathioprine Suppresses inosinic acid synthesis, T and B cell function, Ig production, and IL-2 secretion
Abatacept inhibits activation of T cells
DMARDs Abatacept, azathioprine, chloroquine, hydrochloroquine, cyclophosphamide, cyclosporine, leflunimide, methotrexate, mycophenolate mofetil, rituximab, sulfasalazine
Selective COX-2 inhibitor Celecoxib
Naproxen non-selective COX inhibitor
Ibuprofen reversible COX inhibitor
Ibuprofen less than 2400 mg/day for analgesic. More for anti-inflammatory
Aspirin Low dose: decrease platelet aggregation. Med dose: analgesic and antipyretic. High dose: anti-inflammatory
Aspirin non-selective irreversible COX inhibitor
Complications of NSAIDs Na retention, hypertension, hyperkalemia, decreased renal blood flow, interstitial nephritis
Gastro/renoprotective role of PGE enhance bicarbonate secretion, enhance renal blood flow, enhance blood flow to mucosal surfaces
Montelukast leukotriene antagonist
Zafirlukast Leukotriene antagonist
Zafirlukast increases prothrombin time with warfarin
Zileuton Leukotriene antagonist
Zileuton increase propranolol and theophylline concentrations; increase PT with warfarin
Cortisol Anti-inflammatory at supraphysiologiocal levels
Created by: 511416501



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards