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Anti-inflammatory Rx

Pegloticase recombinant uricase. Use for actively symptomatic gout.
Pegloticase Used for severe gout where other rate-lowering treatments have failed
Pegloticase Catalyzes the oxidation of uric acid into allantoin
Allopurinol inhibits xanthine oxidase
Allopurinol Treatment for chronic tophaceous gout. Especially with renal insufficiency
Febuxostat Newer xanthine oxidase inhibitor.
Sulfinpryazone effects transport sites in middle segment of proximal tubules responsible for reabsorption of uric acid
Sulfinpyrazone can be used as an anti platelet drug
Probenecid effects transport sites in middle segment of proximal tubules responsible for reabsorption of uric acid
Sulfinpryazone more potent than probenecid
Probenecid Results in increase in penicillin, cephalosporins, sulfoamides, and indomethacin
Probenecid blocked by salicylates
Uricosurics Increase excretion of uric acid. Ex: probenecid and sulfinpyrazone
Colchicine given in first 12-36 hours of gout attack
Colchicine antimitotic
Indomethacin NSAID for acute treatment of gout
Acetaminophen indicated for mild to moderate pain and fever.
Acetaminophen Treat overdose with acetylcysteine
Acetaminophen Weak inhibitor of cycloxygenases in peripheral tissue
TNF-α blocking agents Adalimumab, certolizumab, etanercept, golimumab, infliximab
Multiple drug therapy for rheumatoid arthritis Methotraxte with cyclosporine, chloroquine, hydrochloroquine, leflunomide, inflixmab, adalimumab, rituximab, or etanercept.
Sulfasalazine metabolize to sulfapyridine
Sulfasalazine indicated to rheumatoid arthritis
Rituximab Targets CD20 B lymphocytes and depletes them.
Mycophenolate mofetil (MMF) Inhibits T cell proliferation, inhibits E-selectins and P-selectins
Rituximab indicated for arthritis
Mycophenolate mofetil (MMF) Indicated for renal disease due to systemic lupus erthematosus
Methotrexate Used in 50-70% patients with arthritis
Methotrexate Inhibits neutrophil chemotaxis.
Leflunomide Decrease in ribonucleotide synthesis and arrests cells in G1
Leflunomide Indicated for arthritis
Cyclosporine inhibits IL-1 and IL-2 receptor. Inhibits macrophage-Tcell interaction and T cell responsiveness.
Cyclophosphamide Suppress T and B cell function by 30-40 %
Choroquine and hydrochloroquine Indicated for malaria
Azathioprine Suppresses inosinic acid synthesis, T and B cell function, Ig production, and IL-2 secretion
Abatacept inhibits activation of T cells
DMARDs Abatacept, azathioprine, chloroquine, hydrochloroquine, cyclophosphamide, cyclosporine, leflunimide, methotrexate, mycophenolate mofetil, rituximab, sulfasalazine
Selective COX-2 inhibitor Celecoxib
Naproxen non-selective COX inhibitor
Ibuprofen reversible COX inhibitor
Ibuprofen less than 2400 mg/day for analgesic. More for anti-inflammatory
Aspirin Low dose: decrease platelet aggregation. Med dose: analgesic and antipyretic. High dose: anti-inflammatory
Aspirin non-selective irreversible COX inhibitor
Complications of NSAIDs Na retention, hypertension, hyperkalemia, decreased renal blood flow, interstitial nephritis
Gastro/renoprotective role of PGE enhance bicarbonate secretion, enhance renal blood flow, enhance blood flow to mucosal surfaces
Montelukast leukotriene antagonist
Zafirlukast Leukotriene antagonist
Zafirlukast increases prothrombin time with warfarin
Zileuton Leukotriene antagonist
Zileuton increase propranolol and theophylline concentrations; increase PT with warfarin
Cortisol Anti-inflammatory at supraphysiologiocal levels
Created by: 511416501