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degenerative CNS

TermDefinition
What is the pathophysiology behind someone with Parkinson’s disease? There is a destruction of dopamine neurons, causing an imbalance between dopamine (inhibitory) and ACH (stimulatory). The classic triad of S/Sx is bradykinesia, tremors, muscle rigidity, or postural imbalance.
What are 2 goals that drug therapy focuses on? There is no cure for the disease. Goals of drug therapy are (1) increase dopamine levels in the brain, and (2) block the effect of ACH
What are the 2 main groups of drugs to treat Parkinson’s? Anticholinergics and dopaminergic agents Levodopa( Larodopa) Carbidopa( Levadopa)- (Sinemet)
What is Sinemet? What does each component do? Sinemet is the combo drug containing carbadopa and levodopa. Levodopa mimics dopamine (dopamine precursor) that crosses the BBB and stimulates DA production, while carbadopa prevents levodopa metabolism, lengthening the effect of the drug.
What is the patho behind Alzheimer’s Loss of ACH receptors leads to plaque buildup in the CNS and leads to loss of ability to perform ADLs and memory loss.
What classification of drugs is most commonly used to treat Alzheimer’s? How does the drug class work? What is another name for this drug class? Acetylcholinesterase inhibitors, they block the activity of acetylcholinesterases, which allows ACH to remain at the synapse longer. Indirect-acting cholinergic agent
7. What is the patho behind multiple sclerosis? What 2 classifications of drugs did we talk about for MS? How do they work? MS is autoimmune disease characterized by inflammation and eventual loss of myelination in the brain and spinal cord neurons, leads to plaque formation. Drug classifications include immunomodulators and myelin protein builders.
Created by: amyeva22