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Pharm Unit 14
Pharm - Unit 14 Glucocorticoids SPC
Question | Answer |
---|---|
What are Glucocorticoids? | Steriods used to treat inflammation. Interferes with all stages of inflammation. |
What are the three differences in Glucocorticoids? | 1. Cost 2. Side-effects 3. Potency |
Glucocorticoids alter? | The metabolism of Carbs and Protein. Promotes storage of Carbs |
Where are glucocorticoids stored? | Adrenal Glands(above Kidneys) |
How do glucocorticoids effect beta receptors? | Prolong the activity, enhance # of beta receptors(upregulation), and enhances the affinity of beta agonist to beta receptor |
What are the methods of administration? | PO, topical(by any route), IM, IV, inhalationInhalation = low freq. and lower dose, works faster |
3 pharmakonetics? | Effect take hours, minimum dose reqired, dose and time interval is speculative |
What is the purpose of alternative day therapy? | Minimize side effects |
What are side effects noted with long term use? | Fat deposits, abnormal hair growth, muscle atrophy, aseptic necrosis(degradation of large bones), metabolic alkalosis(COPD), high blood sugar, mood swings, anger |
What are some problems with inhaled steroids? | Oral fungus disease(rinse after tx) and bronchospasm |
What are the recommendation for inahlation of steroids? | Larger volume spacer, rinse, fastr acting pre-broncodilator tx, minimal dosing Adults - <800mcg/dayKids <400mcg/day |
DPI steroids? | Beclovent, Vanceril, Pulmicort |
Systemic meds? | Solu-cortef, prenisone, solu-medrol |
How are steroids metabolized and excreted? | Metabolized in the liver and excreted by the kidneys |