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Pharm Unit 13
Pharm - Unit 13 Xanthine Meds SPC
Question | Answer |
---|---|
What are Methylanthines? | Methyl group added to enhance bronchodilation |
What are the natural sources of xanthines? | Tea(theophyline, most effective), Coffee(caffine), and Cocoa(theobromine) |
What are the intended actions of xanthines? | To relax smooth muscle |
What are the Pulmonary effects of Methlxanthines? | Inhibits bronchoconstriction, Reduces PVR(dilates pulmonary blood vessels), Enhances contraction and endurance of diaphragm |
What are the CNS effect of Methylxanthines? | Improves Respiratory drive, may cause anxiety, irritablity, insomnia, tremors, twiching and seizure. B6 may reduce CNS effects |
What are the cardiac effects of Methylxanthines? | Promote vasodilation of coronary arteries, may have + chronotropic and inotropic, can induce arrythmias, tachycardia, palpitations, improves stroke volume |
What are the theraputic blood levels for asthma? COPD? | 5-15 mcg/ml. 10-12 mcg/ml |
Blood levels exceeding 30mcg/ml are associated with? | Arrythmias and seizure |
What are the toxic effects of Methylxanthines? | Mild - nausea, headache, vomitingSerious - seizure/convultionsMay not be a step, may just have convultions |
When cut the dose? | When the half life is extended by CHF, fever, pneumonia or some meds |
When to increase the dose? | When half life is reduced by smokers, High protein diet, or in children(high metabolic rate) |
Methylxanthine Meds include | Theophylline, Aminophylline - H2O soluble, given IV |
Theo-dur, Choledyl, and Lufyllin are? | Most common PO methylxanthines |
What is the effect of methylxanthines on eosinophils? | Causes decreased migration |
How many basic theories of action are there? | Three |
Other effects of methylxanthines? | Diuretic |