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Diurectics

Mechanism of action

Class of diurecticMechanisms of action
osmotics in the proximal tubule decrease sodium and water reabsorption
osmotic in the loop of henle increase medullary blood flow to decrease medullary hypertonicity and reduce sodium and water reabsorption
osmotics in the collecting tuble sodium and water reabsorption decrease becasue of reduced medullary hypertonicity and elevated urinary flow rate
Carbonic anhydrase inhibitors Inhibition of renal carbonic anhydrase decreases sodium bicarbonate reabsorption
Thiazides and thiazide-like Inhibition of Na+/Cl- symporter
Loop or high-ceiling Inhibition of the luminal Na+/K+/2Cl- transport system
Potassium-sparing Inhibition of sodium and water reabsorption by: Competitive inhibition of aldosterone (spironolactone) Blockade of sodium channel at the luminal membrane (triamterene and amiloride)
Created by: lainylaina
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