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Top 200 #3

ClassBrandGenericIndicationsDose FormsRouteAdult/Ped. DosingMOA
K+ Sparing Diuretic/Thiazide Combo Dyazide (capsule); Maxzide (tablet) Triamterene/ Hydrochlorothiazide HTN, Edema Tablet (Maxzide): 37.5/25 or 75/50mg Capsule (Dyazide): 37.5/25 or 50/25mg Oral Triamterene: 37.5-75mg QD HCTZ: 25-50mg QD Ped:N/A Triamterene: K+ sparing diuretic that inhibits reabsorption of Na+ exchange for K+ and H+ by exerting a direct effect on the distal renal tubule
Diuretic Lasix Furosemide HTN, Edema Tablets: 20, 40, 80mg IV/IM Soln.: 10mg/ml Oral Soln.: 10mg/ml or 40mg/5ml Oral, IV, IM 20-80mg TID-QID Ped: 1-2mg/kg/day Anthanilic acid derivative and a potent diuretic that works by blocking the absorption of Na+ and Cl- in the kidney tubules, causing a profound increase in urine output
ACE Inhibitor/ Thiazide Combo Prinzide; Zestoretic Lisinopril/ Hydrochlorothiazide HTN Tablets: Prinzide: 10/12.5 or 20/25 mg Zestoretic: 10/12.5, 20/12.5, 20/25mg Oral 10/6.25 – 80/50mg QD Ped:N/A diuretic and an antihypertensive agent that lowers elevated blood pressure; ACE inhibitor
ACE Inhibitor/ Ca2+ Channel Blocker Lotrel Amlodipine/ Benazepril HTN Capsules: 2.5/10, 5/10, 5/20, 5/40, 10/20, 10/40mg Oral 2.5/10-10/40mg QD Ped:N/A Amlodipine: dihydropyridine Ca2+ channel blocker Benazepril: nonsulfhydryl ACE inhibitor
Beta-Adrenergic Blocker/Thiazide Combo; Cardioselective Tenoretic Atenolol/ Chlorthalidone HTN Tablets: 50/25 or 100/25mg Oral 50/25-100/25mg QD Ped:N/A Atenolol: beta-blocking agent Chlorthalidone: diuretic acting on the cortical diluting segment of the ascending limb of the loop of Henle; increase excretion of Na+ and Cl-
Anticoagulant; Factor Xa inhibitor Xarelto Rivaroxiban Deep Vein Thrombosis, Pulmonary embolism, Prophylaxis, Nonvalvular atrial fibrillation Tablets: 10, 15, 20 mg Oral 10-20mg QD-BID Ped:N/A Rivaroxaban selectively inhibits factor Xa without the need of a cofactor (eg, anti-thrombin III) for activity.
Anticoagulant; Low Molecular Weight Heparin Lovenox Enoxaparin Deep Vein Thrombosis, Prophylaxis, MI Inj. Soln.: 30mg/0.3ml, 40/0.4, 60/0.6, 80/0.8, 100mg/ml, 120/0.8, 150mg/ml SubQ 0.75-1.5mg/kg QD (30-150mg per dose) Ped: 0.5-1.5mg/kg every 12 hours Low molecular weight heparin with anti-Factor Xa and anti-thrombin activities
Anticoagulant; Thrombin Inhibitor Pradaxa Dabigatran Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism Capsules: 75 or 150mg Oral 150mg BID Ped:N/A Competitive, direct thrombin inhibitor which prevents thrombus development. It inhibits both free & clot-bound thrombin as well as thrombin-induced platelet aggregation
Anticoagulant Coumadin; Jantoven Warfarin Atrial Fibrillation, Prophylaxis, Prosthetic Cardiac Valve, Thrombosis, Pulmonary Embolism Tablets: 1, 2, 2.5, 3, 4, 5, 6, 7.5, 10mg IV Powder for Soln. (Coumadin only): 5mg Oral, IV 1-10mg QD Ped:N/A Blocks the regeneration of vitamin K epoxide, thus inhibiting synthesis of vitamin K-dependent clotting factors (2, 7, 9 and 10) and the anticoagulant proteins C and S
ADP-Induced Aggregation Inhibitor; Platelet Aggregation Inhibitor Plavix Clopidogrel Prophylaxis, Thrombosis Tablets: 75 or 300mg Oral 75mg QD Ped:N/A Anticoagulant; prodrug that inhibits platelet aggregation by selectively & irreversibly binding to the ADP P2Y12 receptor on platelets
Parenteral Electrolyte (K+ Supplement) K-Dur; K-Tab; Klor-Con Potassium Hypokalemia, Prophylaxis K-Dur: 20 mEq ER tablet K-Tab: 10 mEq ER tablet Klor-Con: 20 or 25 mEq oral powder for soln., 8, 10, M10, M20 ER tabs Oral, IV 10-100 mEq once to five times daily Ped: Oral: 3-8 mEq/kg/day IV: 0.5-0.75 mEq/kg over 1-2 hrs Electrolyte replenisher that aids in many physiological processes
CNS Agent; Immune Suppressant Copaxone Glatiramer acetate Relapsing remitting Multiple Sclerosis Inj. Soln.: 20mg/ml SubQ 20mg QD Ped:N/A Believed to modify immune processes or functions which are thought to be liable for MS pathogenesis. In vitro studies suggest that glatiramer specific suppressor T-cells are induced & activated in the periphery
Colony Stimulating Factor; Hematopoietic Neulasta Pegfilgrastim Febrile neutropenia in patients with non-myeloid malignancies, Prophylaxis Inj. Soln.: 6mg/0.6ml SubQ 6mg once per chemo cycle (don’t administer between 14 days prior to & 24 hrs after admin of chemo) Ped:N/A A colony stimulating factor that acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional actv’n
Antineoplastic Agent; Monoclonal Antibody Rituxan Rituximab Non-Hodgkins lymphoma, Rheumatoid Arthritis, Chronic Lymphoid Leukemia Inj. Soln.: 10mg/ml IV 375mg/m(2), usually given as part of a scheduled regiment with other meds Ped:N/A MAB that binds to antigen CD20, this disrupts the cell cycle of B-cells resulting in cell lysis and even apoptosis
Aldosterone Receptor Antagonist; K+ Sparing Diuretic Aldactone Spironolactone HTN, Hypokalemia, Ascites, Edema, Aldoseronism Tablets: 25, 50, 100mg Oral 25-400mg QD Ped:N/A Renal competitive aldosterone antagonist; it inhibits the effect of aldosterone by competing for the aldosterone-dependent Na+/K+ exchange site in the distal tubule cells. This increases the secretion of H2O & Na+, while decreasing the excretion of K+
ARB/Thiazide Combo Avalide Irbesartan/ Hydrochlorothiazide HTN Tablets: 150/12.5, 300/12.5, 300/25 Oral 150/12.5-300/25mg QD Ped:N/A ‘sartan: angiotensin II blocker HCTZ: increases excretion of Na+ & Cl- (diuretic/antihypertensive)
ARB/Thiazide Combo Benicar HCT Olmesartan/ Hydrochlorothiazide HTN Tablets: 20/12.5, 40/12.5, 40/25mg Oral 20/12.5-40/25mg QD Ped:N/A ‘sartan: angiotensin II blocker HCTZ: increases excretion of Na+ & Cl- (diuretic/antihypertensive)
ARB/Thiazide Combo Diovan HCT Valsartan/ Hydrochlorothiazide HTN Tablets: 80/12.5, 160/12.5, 160/25, 320/12.5, 320/25mg Oral 160/12.5-320/25mg QD Ped:N/A ‘sartan: angiotensin II blocker HCTZ: increases excretion of Na+ & Cl- (diuretic/antihypertensive)
ARB/Thiazide Combo Hyzaar Losartan/ Hydrochlorothiazide HTN, Prophylaxis Tablets: 50/12.5, 100/12.5, 100/25mg Oral 50/12.5-100/25mg QD Ped:N/A ‘sartan: angiotensin II blocker HCTZ: increases excretion of Na+ & Cl- (diuretic/antihypertensive)
Diuretic; Thiazide HCTZ Hydrochlorothiazide HTN, Edema Tablets: 12.5, 25, 50mg Capsule: 12.5mg Oral 12.5-100mg QD (can be divided) Ped: 1-2mg/kg/day Electrolyte reabsorption inhibitor (resulting in increased excretion of Na+ and Cl- in equal amounts)
Created by: scottamus123
 

 



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