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Cartilage
Histology - Cartilage
| Question | Answer |
|---|---|
| Which part of the body does cartilage belong to? | The skeletal system |
| Is cartilage vascular or avascular? | Avascular |
| What is the consistency of cartilage? | Firm in consistency |
| What are the 3 structures of cartilage? | Matrix, Cells, Perichondrium |
| In cartilage, what are the 2 parts of the matrix? | Ground substance, fibers |
| What is the ground substance in cartilage made up of, chemically? | Glycoproteins and proteoglycans |
| What is the main proteoglycan in ground substance of cartilage? | chondroitin sulfate |
| What is the function of the main proteoglycan of the grounud substance of the cartilage? | Firm consistency of the cartilage matrix |
| What are the fibers of cartilage made up of? | Collagen or elastic, depending on type of cartilage |
| What are cartilage cells called? | chondrocytes |
| What is the shape of chondrocytes? | flat to round cells |
| Groups of chondrocytes are called... | cell nests |
| Another name for cell nests is | Isogneous groupd |
| What are isogneous groups surrounded by? | capsules of matrix |
| What type of cartilage is the perichondrium? | A membrane investing cartilage |
| What is the outer layer of the perichondrium called? | Fibrous layer |
| What is the inner layer of the perichondrium called? | Inner cellular layer |
| What is another name for inner cellular layer | Chondrogenic |
| T/F The chondrogenic layer is poor in blood vessels. | FALSE. The chondrogenic layer is RICH in blood vessels |
| What is the function of the perichondrium? | Nutrition, growth, and regeneration of cartilage |
| What are the two mechanisms of growth of cartilage? | Appositional and Interstitial |
| Describe appositional growth | Adding layers of cartilage on outer surface |
| What is responsible for appositional growth? | Activity of chondrogenic layer of the perichondrium |
| What does interstitial growth mean? | Growth from within |
| How does interstitial growth occur? | Cellular divisions and secretion of cartilage matrix by chondrocytes |
| 3 types of cartilage. | Hyaline, Elastic, and Fibrocartilage |
| Is matrix present in abundance or not at all in hyaline cartilage? | Abundant |
| Describe cells of hyaline cartilage. | Widely separated |
| In hyaline cartilage, how many cells do the cell nests contain? | up to 8 cells. |
| Describe the fibers in the matrix of hyaline cartilage. | No apparent/ no visible fibers. |
| Which cartilage stains basophilic? | Hyaline cartilage |
| Perichondrium is present except... | on articular cartilage |
| Where is hyaline cartilage found? (3) | Costal cartilage, nasal, articular, and some laryngeal cartilages |
| Describe the cells of elastic cartilage. | Cells are condensed with less matrix in between. |
| How many cells do the nests of elastic cartilage contain? | Up to 4 cells |
| What always covers the outer surface of elastic cartiage? | Perichondrium |
| Where is elastic cartilage found? (3) | Cartilage of the ear, Eustachian tube, and some laryngeal cartilage |
| Fibrocartilage has matrix rich in.... | Branching collagen bundles |
| In fibrocartilage, where are chondrocytes located? | Between bundles |
| How do chondrocytes, in fibrocartilage, appear? | Oval, mostly single. |
| Are cell nests common or uncommon in fibrocartilage? | Not common. |
| Cell nests in fibrocartilage are made up of how many cells? | 2 |
| Since fibrocartilage is found in joints, what is special about the perichondrium? | There is none |
| Locations of fibrocartilage... | IVD, cartilage of pubic symphysis, cartilages of the knee joint, cartilage disc of TMJ. |
| What is an IVD made up of, generally? | Annulus fibrosus and Nucleus pulposus. |
| What is the annulus fibrosus? | Outer concentric layers of fibrocartilage |
| What is the nucleus pulposus? | A central mass of gelatinous amorphous material. |
| In what direction fo the collagen fibers of the annulus fibrosus run? | Parallel to each other but in an oblique direction |
| Where do the collagen fibers attach in the IVD? | To hyaline cartilage plate on vert bodies above and below the IVD |
| Where do the outermost layers of the annulus atach? | Directly to the vertebral bone |
| What is the nucleus pulposus made up of? | Chondrocytes, fine collagen fibers, rich in ground substance. |
| How does ground substance react with water? | It binds water into the nucleus. |
| What is replaced as age advances and more and more collagen develops? | The entire nucleus pulposus. |