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Cardiac Failure
Drugs used to treat cardiac failure
Drug name | Type and Mechanism of action |
---|---|
Frusemide | Loop diuretic. Act on Loop of Henle, increase Na secretion, decrease blood volume and BP. |
Chlorothiazide | Thiazide diuretic. Inhibit NaCl co-transport, decrease Na reabsorption, decrease blood volume and BP. |
Enalapril, Perindopril | ACE inhibitor. Inhibit conversion of Ang1 to Ang2. Suppress Ang 2 and Aldosterone production, dilate arteries=decrease after load |
Losartan, Candesartan | Ang1 receptor antagonist. Block action of Ang2 on vessels=decrease preload and after load, decrease contractions. |
Nitrates | Vasodilator. Nitirc oxide donors, dilates veins via cGMP, decrease preload |
Carvedilol | Beta non-selective antagonist. blocks A1=vasodilation, blocks B1= blocks reflex tachycardia, renin release, blocks B2=increase stroke volume. |
Digoxin | Glycoside, inotropic agent. Increase contractility by inhibiting membrane NaKATPase. Enhances parasympathetic activity=vasodilation, decrease HR. |
Milrinone | PDE Inhibitor, inotropic agent. Increases contraction by preventing cAMP breakdown |
Dobutamine, Dopamine | B1 selective agonist. Increases contraction by sympathetic activation. |