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Pharm 01
2nd set
| Term | Definition |
|---|---|
| Butyrophenones | haloperidol and droperidol |
| haloperidol | tourettes syndrome, huntingtons syndrome, for phencyclidine overdose |
| diabenzoxazepines | loxapine |
| thioxanthines | thiothixene |
| Tardive Dyskinesia | due to prolonged therapy with antipsychotics. there's Rhythmic Movement of tongue, lips, jaw |
| Atypical antipsychotic drugs are | Clozapine, Risperidone, Olanzapine. They block dopamine and serotonin receptors |
| clozapine | treat negative signs of schizophrenia |
| risperidone | treat positive / negative signs of schizophrenia |
| olanzapine | treat anti cholinergic effect, sedation. |
| traditional antipsychotics toxic states | CNS sedation, Endocrine alteration, anticholinergic effects |
| antipsychotic malignant syndrome | Patients who are given antipsychotics for long term treatment may go through altered mental status, hypertension, cardiac arrhythmias. |
| Opioid Antagonist | used to relieve intense Pain |
| Opioid antagonist types | Mu, Kappa, Delta, Sigma |
| Mu | seen at supraspinal areas of pain modulation |
| kappa | seen at dorsal horn of spinal grey matter |
| delta | seen at substantia nigra, corpus striatum |
| sigma | seen at hippocampus |
| strong agonist | morphine, fentanyl, heroine, meperidine, methadone, sufentanil |
| antagonist | naloxone, naltrexone |
| mixed agonist / antagonist | buprenorphine, pentazocine |
| moderate agonist | codeine, propoxyphene |
| Morphine | its action are on Mu, Kappa, Sigma Receptors. Its an analgesia. it causes euphoria. it causes respiration depression. there is Miosis Pinpoint pupil. in GIT, there's decrease in motility. in CVS, there's high dose of hypotension |
| Morphine | Cerebral vessel dilate causing brain injury. Histamine release cause bronchoconstriction, Urticaria, sweating and vasodilation. there's increase in prolactin, GH and ADH |
| Morphine | is used to relieve pain in myocardial infarction, pain after surgery, pain seen with trauma. used for epidural anesthesia. to suppress cough. to treat dyspnea. to treat diarrhea. |
| Contraindications of Morphine | Acute respiratory depression, acute pancreatitis, renal failure, chemical toxicity, raised intracranial pressure |
| Drug interaction of Morphine | MAO inhibitors, TCA's, Antipsychotics |
| Fentanyl | its 100 times more powerful than Morphine. it works on Mu, Kappa, and Sigma receptors |
| Heroine | its 2-3 times more powerful than Morphine, it causes Euphoria, its very addictive |
| Meperidine | it works on Kappa Receptors, Route 4 can cause increase in heart rate, Pupil dilates, used for LABOR analgesia, It can replace morphine/Heroine in addicts, its found in Liver |
| Methadone | it works on MU receptors, it has longer duration of action, its found in the liver. its used for withdrawal process for addicts of Heroine and Morphine. |
| Naloxone | Opioid Antagonist, they reverse respiratory depression, it works against Propoxyphene effects. |
| Naltrexone | has longer effect than Naloxone, used in Opiate dependance Maintenance Program |
| Buprenorphine | Agonist on Mu, used on Morphine withdrawal patients |
| Pentazocine | Agonist on Kappa, Antagonist on Mu and Delta receptor |
| Codeine | Good cough suppressant, high sedation rate, high addiction rate |
| Propoxyphene | Gotten from Methadone, pain is MILD - MODERATE. to increase analgesia its used with ASPIRIN or ACETAMINOPHEN. its also used for cough |
Created by:
slinger101
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