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Exogenous depression caused by external factors or life event. ex: death, unemployment
Endogenous depression originates within the body, (MDD) Major Depressive Disorder Ex: chemical imbalance in the brain
Cause of Mental Depression low brain level of Norephinephrine and Seretonin
What is the role of serotonin and norepinephrine Treat mental depression by increasing NE and 5HT level
Antidepressant Drugs that can increase the level of norepinephrine or serotonin in the brain are useful in the treatment of mental depression. These drugs take about 2 to 4 weeks to work fully in the body.
3 classifications of antidepressants Monoamine Oxidase Inhibitors (MAOIs) Tricyclic Antidepressants or (TCAs) Selective Serotonin Reuptake Inhibitors (SSRIs)
Monoamine oxidase (MAO) Enzyme found in most body cells. The function of MAO is to break down norepinephrine and serotonin
Monoamine Oxidase Inhibitors (MAOIs) Drugs that DECREASE the amounts of NE and 5HT that are DESTROYED. Consequently levels of NE and 5HT in the brain will INCREASE.
A pt taking a monoamine oxidase inhibitors (MAOI)must Avoid foods that contain TYRAMINE.
Which foods that contain TYRAMINE must one avoid Ginseng, chocolate, beer, cheese pickles, olives and avocado
Side effects and adverse effects of MAOI Can produce a type of liver damage.
Drug use for Monoamine Oxidase Inhibitors(MAOI) Phenylzine (Nardil)
Tricyclic Antidepressants(TCAs) The main action of the trycyclics is to block the reuptake of norepinephrine and serotonin
Some of the side effects of Tricyclic Antidepressants(TCAs) Sedation and anticholinergic effects. anticholinergic effects are dry mouth, constipation, urinary retention and rapid heart bit.
Tricyclic Antidepressants(TCAs)may produced Effects in the heart and liver and also cause CNS stimulation
Tricyclic Antidepressants(TCAs)are safer Compare to the MAOIS
Selective Serotonin Reuptake Inhibitors (SSRIs) Block the reuptake and inactivation of serotonin in the brain.Fewer side and adverse effects and currently have become the most widely used antidepressant.Have very little action to block cholinergic receptors
Drugs for Selective Serotonin Reuptake Inhibitors (SSRIs) Sertraline (Zoloft) 50 - 200 mg/day fluoxetine (Prozac) 20 - 40 mg/day
Prozac Does not mix well with anticoagulants and benzodiazepines. Also effective in the treatment of OCD
Side effects of (SSRIs) involve the CNS and the gastrointestinal tract.
Adverse effects of (SSRIs) 1) Weight loss 2) Insomnia 3) Tremors 4) Nervousness
Atypicals SSRIs Second group of SSRIs and block reuptake of multiple neurotransmitter ( NE, 5HT and Dopamine)
Drugs for Atypicals SSRIs Bupropion (Wellbutrin) Venlafaxine (Effexor)
Duloxetine (Cymbalata) Escitalopram (Lexapro) Drug used if you have depression, diabetic neuropathy pain, fibromyalgia, generalized anxiety disorder, or chronic pain,
Drugs for Tricyclic Antidepressants(TCAs) Nortriptyline (Aventyl) Amitriptyline (Elavil) Doxepin (Sinequan) Imipramine (Tofranil)
Created by: edbalallo



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