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Pharmacology 46 Parkinsons

First described by Dr. James Parkinson in 1817 as a "shaking palsy". Parkinsons Disease (M2/49)
Clinical signs and symptoms of PD result when ______% of dopaminergic neurons are lost. 80% (M2/50)
If PD present with postural instability and gait difficult - more _______ progression. rapid (M2/50)
Without dopamine neurons, dopamine can't inhibit cholinergic neurons. Cholinergic neurons form excitatory synapses and no dopamine to inhibit _______ neurons. So unopposed _______, which manifests as tremors. cholinergic acetycholine (M2/51)
Found in patient w PD. Proteins that clump together inside neurons in the midbrain. Unknown whether they damage neurons or if they are result of damaged neurons. Lewy bodies (M2/51)
If Lewy bodies are present, ______ _______ is also present. neuronal degeneration (M2/51)
Does Dopamine cross the blood brain barrier? No (M2/54)
What drug can be given as a dopamine precursor and is a metabolic precursor of dopamine and does cross the blood brain barrier? Levodopa (M2/55)
Levodopa is decarboxylated to dopamine while it's still in the periphery, need larger doses, lot of side effects from dopamine floating around, and ____ years limited use. 5 years (M2/56)
Most common neurodegenerative disorder after Alzheimer's Disease. Parkinson's Disease 503
Damage to neurons by amyloid results in excess _________ & diminished ________ in the basal ganglia in PD. acetylcholine dopamine 503
To improve symptoms of PD, the medications must be able to cross the _____ _____ ______ without being metabolized in the periphery. blood brain barrier 504 (M2/54)
Black box warning from FDA indicates antipsychotics (Seroquel & Abilify) should not be used in PD b/c appear to increase the risk of death in _____ ______ patients. older dementia 506
Used for acute treatment of episodes of immobility known as freezing in PD. Apomorphine injection 506
Reduce tremor, rigidity, and drooling, older drugs with limited use in PD. Anticholinergices 506
What are the initial drugs for the first line of PD? levodopa, dopamine agonists, rasagiline 506
Less likely than levodopa to cause dyskinesias or motor fluctuations, may be given with or before levodopa. Dopamine agonists 506
All PD patients will eventually need _____/______. carbidopa/levodopa 506
Side effects include confusion, blurred vision, dry mouth, constipation, urinary retention, hallucinations, and psychosis Anticholinergics (M2/63) worse in older adults
Created by: mareed3



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