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Antihipertensive

QuestionAnswer
Clase de AntiHTA Simpatolitice, blocante de Ca, Diuretice, VD, Inhib Izo
Simpatolitice (medicamente) - inhib simp prin act centrala clonidina, metildopa, moxonidina
Ganglioplegice (medicament - mecanism) antagonisti competitivi (cu acth) pe receptorii nicotinici -> trimetafanul (disectie de aorta , hta urgente)
Blocante ale terminatiilor simpatice (medicamente) guanitidina, rezerpina
Mecanisme guanitidina si rezerpina g - scade captarea CA din fanta (TA creste putin dupa care scade mult) , r - scade captarea na, dopa, ser in granule
Blocante alfa adrenergice (medicamente) neselective: fentolamine, tolazolina (feocromocitom)....selective alfa1: prazosin , terazosin,doxazosin
VD hidralazina, minoxidil, diazoxid, nitroprusiatul de sodiu(RA: methemoglobinemie)
Reactii adverse VDuri hidralazina ( polinevrite periferice, sdr.lupoid, anemie, leucopenie, trombocitopenie), minoxidil ( retentie hidrosalina majora si hipertricoza) , diazoxid (efect hiperglicemiant (ca diureticele de tip tiazidic!!!) prin scaderea secretiei de insulina)
Blocante de Ca dihidropiridine: nife, amlo, felo,nicardipina benzodiazepine: diltiazem fenilalchilamine: verapamil
Mecanisme blocante Ca DHP- VD perif cu tahicardie reflexa benzo + fenil : deprimare cord -> scad DC -> scad TA
IEC captopril, enalapril, lisinopril
Created by: rapul