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Pharmacology 42 Dementia

Two classes of medications for Dementia? Cholinesterase inhibitors, NMDA receptor antagonists 457 (M2/34)
What is a chronic neurodegenerative illness characterized by cognitive and functional decline, as well as emergent behavioral disturbances. Alzheimer's disease (AD)..Dementia? 457 (M2/31) Which?
Shrinkage of large cortical neurons, loss of snapses, shrinkage of dendrite arbor of large neurons (critical substrate) is what? Patho of AD Alzheimer's disease 458 (m2/32)
AD and vascular dementia are the most common causes of __________. Dementia 458 (M2/32)
Cholinesterase inhibitors are the first line treatment for __________. AD (M2/34) 458
____________ is enzyme which breaks down acetylcholine relased at synapse. Acetylcholinesterase 458 (M2/35)
_______ _________ block the enzyme that degrades acetylcholine in the brain. Cholinesterase inhibitors 458 (M2/35)
Excessive stimulation of the ________ receptor, however leads to excitotoxicity. NMDA 458 (M2/36)
________ also used off-label for: mild to mod dementia, catatonic schizophrenia, PD, neurogenic bladder, & phantom limb syndrome. NMDA Blocker 458 (M2/36)
EBP research suggests cholinesterase inhibitors may stabilize cognitive & functional ability around a _____ in AD. year 459 (M2/37)
Effectivness of AD tx wears off as dz worsens and as _______ neurons are _________, more, destroyed 459 (M2/37)
_________ may be used in AD is controversial and should be used no longer than 6 months. Abruptly stopping doubles risk of AD symptom relapse. Antipsychotics 459 (M2/37)
medication demonstrated a benefit for patients with dementia with Lewy bodies and for those with dementia associated with Parkinson's disease. Rivastigmine cholinesterase inhibitor 460
None of the drugs available for ________ alter the underlying pathology. they produce only a marginal improvement in symptoms. Dementia S91
What are the two classes of drugs used in dementia? Cholinesterase inhibitors, NMDA anatagonist S91
__________ is the enzyme that breaks down synaptically released acetylcholine. Acetylcholinesterase S91
Other cholinesterase inhibitors have been used as nerve gases or tx of _______ _______. myasthenia gravis S91
_________ is a noncompetitive anagonist at the NMDA subtype of glutamate receptor. Memantine - NMDA blocker S92 (M2/36)
Created by: mareed3



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