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Pharmacology
Pharmacology 42 Dementia
| Question | Answer |
|---|---|
| Two classes of medications for Dementia? | Cholinesterase inhibitors, NMDA receptor antagonists 457 (M2/34) |
| What is a chronic neurodegenerative illness characterized by cognitive and functional decline, as well as emergent behavioral disturbances. | Alzheimer's disease (AD)..Dementia? 457 (M2/31) Which? |
| Shrinkage of large cortical neurons, loss of snapses, shrinkage of dendrite arbor of large neurons (critical substrate) is what? | Patho of AD Alzheimer's disease 458 (m2/32) |
| AD and vascular dementia are the most common causes of __________. | Dementia 458 (M2/32) |
| Cholinesterase inhibitors are the first line treatment for __________. | AD (M2/34) 458 |
| ____________ is enzyme which breaks down acetylcholine relased at synapse. | Acetylcholinesterase 458 (M2/35) |
| _______ _________ block the enzyme that degrades acetylcholine in the brain. | Cholinesterase inhibitors 458 (M2/35) |
| Excessive stimulation of the ________ receptor, however leads to excitotoxicity. | NMDA 458 (M2/36) |
| ________ also used off-label for: mild to mod dementia, catatonic schizophrenia, PD, neurogenic bladder, & phantom limb syndrome. | NMDA Blocker 458 (M2/36) |
| EBP research suggests cholinesterase inhibitors may stabilize cognitive & functional ability around a _____ in AD. | year 459 (M2/37) |
| Effectivness of AD tx wears off as dz worsens and as _______ neurons are _________, | more, destroyed 459 (M2/37) |
| _________ may be used in AD is controversial and should be used no longer than 6 months. Abruptly stopping doubles risk of AD symptom relapse. | Antipsychotics 459 (M2/37) |
| medication demonstrated a benefit for patients with dementia with Lewy bodies and for those with dementia associated with Parkinson's disease. | Rivastigmine cholinesterase inhibitor 460 |
| None of the drugs available for ________ alter the underlying pathology. they produce only a marginal improvement in symptoms. | Dementia S91 |
| What are the two classes of drugs used in dementia? | Cholinesterase inhibitors, NMDA anatagonist S91 |
| __________ is the enzyme that breaks down synaptically released acetylcholine. | Acetylcholinesterase S91 |
| Other cholinesterase inhibitors have been used as nerve gases or tx of _______ _______. | myasthenia gravis S91 |
| _________ is a noncompetitive anagonist at the NMDA subtype of glutamate receptor. | Memantine - NMDA blocker S92 (M2/36) |
Created by:
mareed3
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