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Ch 31
Anticoagulants
| Generic Name | Trade Name | Mech of Action | Uses | Side Effects | Classification |
|---|---|---|---|---|---|
| Heparin | Heparin | Inhibit Faxtor Xa & IIa. Inhibit platelet function. Inc. Vascular permeability | (blank) | thrombocytopenia, bleeding, nosebleed, bruising misc bleeding | IV AntiCoagulant |
| ardeparin | Normiflo | Inhibit Factor Xa | Surgery, unstable MI pt. treat DVT/PE | redness, itching, bruising, thrombocytopenia, bleeding | Low Molecular Weight Heparin |
| Dalteparin | Fragmin | Inhibit Factor Xa | surgery, unstable MI pt. treat DVT/PE | thrombocytopenia, redness, itching, bruising, bleeding | Low Molecular Weight Heparin |
| enoxaparin | Lovenox | Inhibit Factor Xa | Surgery, unstable MI pt. Treat DVT/PE | thrombocytopenia, bleeding, redness, itching, bruising | Low Molecular Weight Heparin |
| Warfarin | Coumadin | Interferes c synthesis of Vit K dependent factors. II, VII, IX, X, | Treat DVT. Prevent recurrent venous thromboembolism | alopecia, anorexia, abdominal cramps, N/V/D, bleeding | Oral Anticoagulant |
| streptokinase | Streptase | Dissolve Clots via endogenous fibrinolytic system | Treat acute DVT, pulmonary thromboembolism, Coronary arterial Thrombosis, ischemic stroke | (blank) | Thrombolytic Drug |
| Acetyl Salicylic acid | Aspirin, ASA | Irreversibly inhibits platelet aggregation | prevention of thrombus | Gastric Distress, GI bleeding, bleeding | Antiplatelet Drug |
| Cilostazol | Pletal | Inhibits cAMP levels, vasodilation, inhibits platelet aggregation | Intermittent claudication | Headache, pharyngitis, N/D, peripheral edema | Antiplatelet Drug |
| Clopidogrel | Plavix | Inhibits ADP, doesn't cause neutropenia, use instead of Ticlid | Prophylaxis of MI, thromboembolic stroke & vascular death | DI distress, headache, weaknes N/V/D, rash | Antiplatelet Drug |
| Dipyradamole | Persantine | inhibits platelet aggregation | prevention of postsurgical thromboembolic complications after cardiac valve replacement | headache, dizziness, abdominal upset, rash | Antiplatelet Drug |
| Ticlopidine | Ticlid | Inhibit platelet-fibrinogen binding | Decrease risk of stroke | neutropenia (need lab draws) | Antiplatelet Drug |
| Aminocaproic acid | Amicar | inhibits fibrinolysis when excessive bleeding occurs | (blank) | N/D, edema, weight gain, severe muscle pain, slow or irregular heart rate | Hemostatic Drug |