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Ch 31

Anticoagulants

Generic NameTrade NameMech of ActionUsesSide EffectsClassification
Heparin Heparin Inhibit Faxtor Xa & IIa. Inhibit platelet function. Inc. Vascular permeability (blank) thrombocytopenia, bleeding, nosebleed, bruising misc bleeding IV AntiCoagulant
ardeparin Normiflo Inhibit Factor Xa Surgery, unstable MI pt. treat DVT/PE redness, itching, bruising, thrombocytopenia, bleeding Low Molecular Weight Heparin
Dalteparin Fragmin Inhibit Factor Xa surgery, unstable MI pt. treat DVT/PE thrombocytopenia, redness, itching, bruising, bleeding Low Molecular Weight Heparin
enoxaparin Lovenox Inhibit Factor Xa Surgery, unstable MI pt. Treat DVT/PE thrombocytopenia, bleeding, redness, itching, bruising Low Molecular Weight Heparin
Warfarin Coumadin Interferes c synthesis of Vit K dependent factors. II, VII, IX, X, Treat DVT. Prevent recurrent venous thromboembolism alopecia, anorexia, abdominal cramps, N/V/D, bleeding Oral Anticoagulant
streptokinase Streptase Dissolve Clots via endogenous fibrinolytic system Treat acute DVT, pulmonary thromboembolism, Coronary arterial Thrombosis, ischemic stroke (blank) Thrombolytic Drug
Acetyl Salicylic acid Aspirin, ASA Irreversibly inhibits platelet aggregation prevention of thrombus Gastric Distress, GI bleeding, bleeding Antiplatelet Drug
Cilostazol Pletal Inhibits cAMP levels, vasodilation, inhibits platelet aggregation Intermittent claudication Headache, pharyngitis, N/D, peripheral edema Antiplatelet Drug
Clopidogrel Plavix Inhibits ADP, doesn't cause neutropenia, use instead of Ticlid Prophylaxis of MI, thromboembolic stroke & vascular death DI distress, headache, weaknes N/V/D, rash Antiplatelet Drug
Dipyradamole Persantine inhibits platelet aggregation prevention of postsurgical thromboembolic complications after cardiac valve replacement headache, dizziness, abdominal upset, rash Antiplatelet Drug
Ticlopidine Ticlid Inhibit platelet-fibrinogen binding Decrease risk of stroke neutropenia (need lab draws) Antiplatelet Drug
Aminocaproic acid Amicar inhibits fibrinolysis when excessive bleeding occurs (blank) N/D, edema, weight gain, severe muscle pain, slow or irregular heart rate Hemostatic Drug
Created by: rvr_rat
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