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rt 141 final review
review
Question | Answer |
---|---|
Law of Bergone and tribondeau | 1906 - It states that the radiosensitivity of cells is directly proportional to their reproductive activity and inversely proportional to their degree of differentiation. |
Oxygen Enhancement Ratio | Radiation dose required to cause biologic response without O2 OER= ---------------------------------------------------------- Radiation dose required to cause biologic response with O2 |
What is Fractionation? | Equal doses planned out over time. Deterministic. |
Protraction is? | Radiation dose over a long period of time, but its not equal.Protagonistic. |
Relative Biological Effectiveness formula. | Effect of a dose of x rays (250 KeV for ex.) RBE= -------------------------------------------------------------- Effect of a dose of another type of radiation delivered under the same circumstances. |
Non-Linear - Threshold (Non Stochastic/ Deterministic Effects) | Large dose/ Short time ; early effects, short term somatic. An increase in the dose will increase severity of response. |
Linear- Non - Threshold (Stochastic/ Probabilistic Effect) | Small dose/ Long time ; long term somatic effects. Cancers, leukemia, cataracts, Genetic effects are suspected. An increase in dose will increase likelihood but not severity of response. |
LD 50/30 | Lethal dose of radiation that will kill 50% of the population in 30 days. 700 RADs for whole population. |
Stages of radiation sickness? | 1. Prodromal or initial- N-V-D 2. Latent- Fine for now. 3. Manifest illness- Very sick. 4. Recovery or Death- self explanatory. |
Cellular Responce | The visible or detectable structural or functional changes produced by a given dose within a given period of time. |
RBE? | Relative Biological Effectiveness, RBE escalates as LET increases. |
Low LET | X ray and Gamma, travels far, not very damaging. |
Has a moderately high LET | Beta particle, travels further than Alpha but not quite as damaging. |
Has a high LET | Alpha particle, doesn't travel very far, very damaging. |
LET is | Linear energy transfer- The average energy deposited per unit length of track. |
How does ionizing radiation damage living systems | By ionizing (removing electrons from) the atoms comprising the molecular structures of these systems. |