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Fungal Infections

Fungal SpeciesGeographic AreaseverityDrug of ChoiceAlternate
Aspergillus everywhere Invasive Voriconzaole Lipo Ampho B, Caspofungin, Micafungin, Posaconazole
Aspergillus (empiric) Lip Ampho B Caspofungin, Itraconazole, Voriconazole
Aspergillus (PPX) Posaconazole
Blastomycosis southeastern/south central states bordering Mississippi/Ohio rivers, Great Lakes, A\St. Lawrence Seaway Life Threatening/Severe (Pulmonary, Disseminated, Immunocompromised) Lip Ampho B Itraconazole
Blastomycosis southeastern/south central states bordering Mississippi/Ohio rivers, Great Lakes, A\St. Lawrence Seaway mild/moderate (pulmonary, disseminated) Itraconazole
Histoplasmosis Ohio/Mississippi River valleys Severe/CNS Ampho B Itra
Histoplasmosis Ohio/Mississippi River valleys Mild Itraconazole
Coccidioidomycosis SW deserts (CA,AZ, NM, NV, TX) all severities Fluconazole Lip Ampho B, (CNS - intrathecal ampho B)
Cryptococcosis C. neoformans - world wide C. gatti - tropics/subtropics, Australia, Pacific Northwest CNS/disseminated/severe Lip Ampho B + flucytosine Fluconazole
Cryptococcosis C. neoformans - world wide C. gatti - tropics/subtropics, Australia, Pacific Northwest mild/moderate (not brain) fluconazole
Mucormycosis everywhere (requires aggressive surgical debridement) Ampho B Posaconazole
Candida Albicans everywhere fluconazole
Candida Glabrata everywhere echinocandins (caspofungin, etc.)
Created by: 1450725958