Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove Ads
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how


Anticoagulants, Plt inhibitors, Fibrinolytics

fibrinolytics lyse formed clots by dissolving fibrin; tPA (alteplase), ; do not prevent clots; act by activating plasminogen to form active plasmin
tPA (alteplase) (human/recombinant tissue plasminogen activator) (selective, non-antigenic since its human in origin) converts plasminogen (inactive) to plasmin (active), site-specific for plasminogen only when bound to fibrin clot, bind to newly formed thrombus with high affinity b/c its specific to new formed clots, used to open blocked coronary arteries&dissolve clot
plasmin active form dissolves fibrin, clot dissolves, plt break apart into circulation
plasminogen inactive PRO produced in liver, built into plt plug sits there until clot is no longer needed then plasminogen will activate
Cons with tPA systemic lysis of other clots and bleeding
Do not use tPA with pts w/recent strokes why? tPA will open up clot = bleeding; use caution
other plasminogen activators streptokinase, tenecteplase, reteplase
streptokinase plasminogen activator, fibrinolytic protein, bacterial origin (beta-hemolytic streptococci), powerful, antigenic, non-specific; used for ST-elevation MI, pulmonary embolism
Tenecteplase & Reteplase plasminogen activator, fibrinolytic modified version of tPA, longer half-life and more fibrin specific than tPA, given IV bolus
The activation of plasminogen to plasmin is done by what? activated by tPA
Created by: cburrows