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Psychoses Prototypes

NameTherapeutic ClassPharmacologic Class
Chloropromazine Hydrochloride MOA blocks positive symptoms of schizophrenia
Chloropromazine Hydrochloride primary use for severe mental illness
Chloropromazine Hydrochloride adverse effects acute dystonia, akathisia, Parkinsonism, tardive dyskinesia, anticholinergic effects, sedation, hypotension, sexual dysfunction, and neuroleptic malignant syndrome
Haloperidol (Haldol) conventional antipsychotic; schizophrenia drug D2 dopamine receptor antagonist; nonphenothiazine
Haloperidol MOA blocking dopamine type 2 receptor
Haloperidol primary use severe mental illness Treat acute and chronic psychoses Treat schizophrenia, Tourette’s syndrome, dementia
Haloperidol adverse effects and contraindications identical to that of phenothiazines Narrow-angle glaucoma; severe liver, kidney and cardiovascular disease; blood dyscrasias, sedation
Haloperidol side effects Sedation, EPS, headache, seizures Dry mouth, blurred vision, photosensitivity, urinary retention Tachycardia, orthostatic hypotension, dysrhythmias
Risperidone (Risperdal) atypical antipsychotic; schizophrenia drug D2 dopamine receptor antagonist (weaker affinity for D1 receptors); serotonin (5-HT) receptor antagonist
Risperidone MOA block dopamine type 2 receptors, serotonin and alpha-adrenergic receptors
Risperdone primary use severe mental illness; treats both positive and negative symptoms
Risperdone adverse effects fewer than those of phenothiazines and nonphenothiazines, but obesity and its risk factors need to be monitored
Chloropromazine Hydrochloride (Thorazine) Conventional antipsychotic; schizophrenia drug D2 dopamine receptor agonist; phenothiazine
Created by: libbygrace7



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