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Psychoses Prototypes
Name | Therapeutic Class | Pharmacologic Class |
---|---|---|
Chloropromazine Hydrochloride MOA | blocks positive symptoms of schizophrenia | |
Chloropromazine Hydrochloride primary use | for severe mental illness | |
Chloropromazine Hydrochloride adverse effects | acute dystonia, akathisia, Parkinsonism, tardive dyskinesia, anticholinergic effects, sedation, hypotension, sexual dysfunction, and neuroleptic malignant syndrome | |
Haloperidol (Haldol) | conventional antipsychotic; schizophrenia drug | D2 dopamine receptor antagonist; nonphenothiazine |
Haloperidol MOA | blocking dopamine type 2 receptor | |
Haloperidol primary use | severe mental illness Treat acute and chronic psychoses Treat schizophrenia, Tourette’s syndrome, dementia | |
Haloperidol adverse effects and contraindications | identical to that of phenothiazines | Narrow-angle glaucoma; severe liver, kidney and cardiovascular disease; blood dyscrasias, sedation |
Haloperidol side effects | Sedation, EPS, headache, seizures Dry mouth, blurred vision, photosensitivity, urinary retention Tachycardia, orthostatic hypotension, dysrhythmias | |
Risperidone (Risperdal) | atypical antipsychotic; schizophrenia drug | D2 dopamine receptor antagonist (weaker affinity for D1 receptors); serotonin (5-HT) receptor antagonist |
Risperidone MOA | block dopamine type 2 receptors, serotonin and alpha-adrenergic receptors | |
Risperdone primary use | severe mental illness; treats both positive and negative symptoms | |
Risperdone adverse effects | fewer than those of phenothiazines and nonphenothiazines, but obesity and its risk factors need to be monitored | |
Chloropromazine Hydrochloride (Thorazine) | Conventional antipsychotic; schizophrenia drug | D2 dopamine receptor agonist; phenothiazine |