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Seizure Prototypes

NameTherapeutic ClassPharmacologic Class
Diazepam(Valium) Antiseizure Drug Bezodiazepine; GABA receptor agonist
Phenytoin(Dilantin) Antiseizure Drug; antidysrhythmic Hydantoin; sodium influx-suppressing drug
Valproic Acid(Depakene) Antiseizure drug Valproate
Ethosuximide(Zarontin) Antiseizure Drug Succinimide
Dilantin mechanism of action to desensitize sodium channels
Dilantin primary use treating all types of epilepsy except absense seizures
Dilantin adverse effects CNS depression, gingival hyperplasia, skin rash, cardiac dysrhythmias, and hypotension
Valproic Acid mechanism of action to densensitize sodium channels
Valproic acid primary use for absence seizures
Valproic acid adverse effects and additional adverse reactions limited CNS depression, visual disturbances, ataxia, vertigo, headache gastrointestinal effects, hepatotoxicity, pancreatitis
Ethosuximide mechanism of action suppress calcium influx
ethosuximide primary use for absence seizures
ethosuximide adverse effects and rare but serious side effects rare but include drowsiness, dizziness, lethargy systemic lupus erythematosis, leukopenia, aplastic anemia, Stevens-Johnson syndrome
Phenobarbital MOA enhance activity of GABA
Phenobarbital primary use treat partial seizures and status epilepticus; also treats seizures due to meningitis, toxic reactions, eclampsia
Phenobarbital side effects/ adverse reactions Less pronounced than phenytoin Sedation Tolerance
Phenobarbital(Luminal) Antiseizure drug; sedative Barbituate, GABA Receptor agonist
Created by: libbygrace7