Save
Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

MS - block 6

Pharm'14 block 2

NameMOAUSEAE/BBContra/InterMonitor/Pearls
Glatimer Acetate (copaxone) May promote proliferation of T2 helper cells (neuroprotective), compete with myelin basic protein thereby inhibiting re-activation of the T-cells in the CNS RRMS CIS Lipoatrophy (dimpling of skin) injection reaction chest pain (tach, SOB, CP) not immune suppressing NO lab monitoring: big benefit
Fingolimod (gilenya) sequestrating of lymphocytes into the lymph node thus decreasing lymphocyte migration into the CNS RRMS Low WBC -> around 2 1st degree heart block bradycardia macular edema Cardiac Problems immune suppressing monitor 1st dose EKG monitor: CBC, LFT, OTC every 3-6 months
Natalizumab (tysabril) binds to the surface of Tcells, Bcells and macrophages -> prevents movement across the BBB JC virus activation -> PML infections infusion reactions elevated LFTs prescreeen LFTs and JC virus
Dimethyl fumarate (tecfidera) unknown: thought to decrease activated T1 helper cells (proinflammatory) and increase T2 helper cells (neuroprotective) RRMS GI upset (30%) N/V/D Flushing; eat w/ meal or take ASA elevated LFTs prescreen: CBC Monitoring: CBC, CMP
Teriflunomide (aubagio) inhibiting pyrimidine synthesis -> decreases proliferation of T and Bcells in periphery RRMS elevated LFTs Alopecia Diarrhea BBW: sever liver dz Preg X prescreen lab: LFTs, CBC, TB monitor LFTs monthly for 6 then every 6 slowly eliminated from plasma (8months - 2yrs)
Interferon Beta 1a (avonex) Not sure-> Think: decrease TCell proliferation, decrease antigen prentation, andalter cytokine release which reduces the number of cells that cross through the BBB RRMS CIS Flu-like sx depression -> ceases within months injection site reactions elevated LFTs Hypothyroidism Not immune suppressing Monitor : CBC, LFT, TSH
Created by: duanea00
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards