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Clin Path I

Quiz #1 - Leukemia, Lymphomas, Myeloproliferative Syndromes

Hodgkin's Lymphoma: basic neoplastic cell is ____. Name the two subtypes malignant reticulum cell. Classic Hodgkin Lymphoma (95%) Nodular Lymphocyte Predominant Hodgkin Lymphoma (5%)
Hodgkin's Lymphoma: Ratio M/F M 1.4: F 1.0
Hodgkin's Lymphoma: Clinical Findings - organs - symptoms Lymph - Spleen - Liver - Intense pruritus early, Pel-Ebstein cyclic fever pattern, *immediate pain after drinking alcohol
Hodgkin's Lymphoma: Labratory findings - WBCs - Differential - Others PMN leukocytosis, *lymphocytopenia, elevation of serum alkaline phosphatase (bone marrow or liver involvement), elevated ESR (active disease), *Reed-Sternberg cells found in blood smears
Hodgkin's Lymphoma: classic signs/sx (3) fever of unknown origin, pruritis, lymphadenopathy
Bad lymph nodes nontender, nonmobile, firm, not well delineated
Polycythemia Vera: definition myeloproliferative clonal disorder that is a cancer of stem cells in the bone marrow leading to increased RBCs WBCs and platelets.
Polycythemia Vera: causes primary - cancer of stem cells secondary - increased RBCs due to hypoxia relative - dehydration
Polycythemia Vera: symptoms/exam bone tenderness centrally, organomegaly, facial plthora, skin excoriations, gouty tophi, HTN, retinal veins engorged
Polycythemia Vera: lab findings -CBC EPO decreased RBC increased Thrombocytosis (>400K) - malignancy Leukocyte Alkaline Phosphatase increased
Polycythemia Vera: management Phlebotomy to reduce hematocrit, maintain hydration, uric acid reduction, avoid iron in diet
General Leukemia: in acute leukemia, predominant cell is the ____. Usually more than __% of these cells in the peripheral blood. Can be due to ____ or ____. blast, 25%, ionizing radiation or chemical leukemogens
General Leukemia: Clinical findings - 3 main findings - organs - symptoms *anemia, thrombocytopenia, and infections* splenomegaly (extramedullaryhemaopoeisis), lymphadenopathy, renal problems bone pain increased intracranial pressure, fever, anemia, hemorrhage, infection
ALL - definition - age Acute Lymphoblastic Leukemia - pediatric, WBC production with excess lymphoblasts - age 2-5
ALL - history (symptoms) - treatment Acute Lymphoblastic Leukemia -bleeding, joint pain, anemia (fatigue, pallor, HA) - methyltrexate treated
ALL - lab findings Acute Lymphoblastic Leukemia - anemia in 90% of patients - thrombocytopenia - leukemic lymphoblasts in blood smear
AML - definition - Physical exam - ___ m/c type - lab findings Acute Myeloid Leukemia - proliferation of immature myeloid blasts, leads to bone marrow failure - general leukemia findings - 2nd M/C leukemia - anemia, thrombocytopenia, WBC count increased, *Auer rods
CLL - definition - ____ m/c type - history - lab findings Chronic Lymphocytic Leukemia - proliferation of mature but incompetent lymphocytes - most common leukemia in adults - insidious, general leukemia symptoms - *lymphocytosis (>5000 lymphocytes/uL), *smudge cells
CML - definition - hallmark chromosome - history - lab findings Chronic Myelogenous Leukemia - proliferation of myeloid precursors leading to mature granulocytes - hallmark is Philadelphia chromosome - splenomegaly may cross midline
CML - lab findings Chronic Myelogenous Leukemia - WBC count markedly increased (50-100K), smear shows all stages of differentiation, *eosinophil and basophil concentrations markedly increased*
Created by: dwagnerchiro