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CF exacerbation

Peds CF exacerbation treatment

empiric po tx for MSSA cefuroxime, amox/clav, sulfmethoxazole/trimethoprim
empiric po tx for PSA ciprofloxacin
empiric iv tx for MSSA cefuroxime or oxacillin or cefepime
empiric iv tx for MRSA vanco +/- rifampin
empiric iv tx for PSA double coverage: aminoglycoside (gent, tob, amikacin) + ceftazidime or cefepime, pip/taz or tic/clav, imipenem/cliastatin or meropenem (2nd line), cipro (last line)
tx for CF exacerbation with B cepacia and/or S maltophilia combination of 2-3 drugs: aminoglycosides, B-lactams (pip/tazo, ceftazidime, carpapenem), cloramhenicol, colistatin, fluoroquinolones, sulfamethoxazole/trimethoprim
CF exacerbation w/ history of MSSA/no PSA colonization cefuroxime or nafcillin or oxacillin
CF exacerbation w/ history of MSSA and PSA colonization double PSA coverage: cefepime + aminoglycoside
CF exacerbation w/ history of MRSA/no PSA colonization vanco +/- rifampin
CF exacerbation w/ history of MRSA and PSA colonization vanco +/- rifampin plus double PSA coverage aminoglycoside + B-lactam (ceftazidime)
Created by: Kachmiel