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anti-epileptics

QuestionAnswer
drugs work on ____ channels, NOT ____ channels inactivated, closed
drugs that work on sodium channels carbamazepine, lamotrigine, phenytoin, VPA
drugs that work on GABA-A receptors clonazepam, diazepam, lorazepam, phenobarbitol
do not use ___ for absence seizures, instead use ____ NO: benzos YES: ethosuximide and VPA
used 2nd line for partial and generalized tonic-clonic phenobarbital
phenobarbital MOA increases duration of opening for GABA-A receptor
phenobarbital SE sedation, toxicity, tolerance, CYP450 inducer
first line for febrile seizures in children phenobarbital
used for partial/general tonic-clonic and status epilepticus phenytoin
MOA phenytoin voltage-gated Na channels
phenytoin SE diplopia, ataxia, rashes, hisutism, gingival hyperplasia
which drug has nonlinear kinetics that may result in rapid increases in serum concentration in response to small doses phenytoin
first line for partial and general tonic clonic carbamazepine
MOA carbamazepine voltage gated Na channels
SE carbamazepine diplopia, ataxia
used for trigeminal neuralgia carbamazepine
which drug may induce aplastic anemia and agranulocytosis carbmazepine
DOC for myoclonic...also used for absence, partial and general VPA
MOA for VPA voltage gated Na channels, T-type ca channels (at higher concentrations)
SE for VPA hepatotox, developmental abnormalities for pregnant women
monitoring for VPA LFTs and pregnancy
used for refractory partial seizures lamotrigine
lamotrigine MOA voltage-gated Na channels
SE for lamotrigine SJS
benzo used for absence and myoclonic seizures in children clonazepam
clonazepam MOA increases frequency of opening for GABA-A receptors
SE of clonazepam low toxicity, drowsiness, fast tolerance
benzos used IV for status epilepticus diazepam, lorazepam
MOA for diazepam, lorazepam GABA-A
SE for diazepam, lorazepam sedation and tolerance
used for partial and secondarily generalized seizures vigabatrin
vigabatrin MOA irreversible inhibition of GABA transaminase, and blocks GABA transporter
which drug is used for West syndrome, a rare infant epilepsy vigabatrin
SE for vigabatrin visual field defects and psych problems
DOC for uncomplicated absence ethosuximide
MOA for ethosuximide T-type Ca channels
what is the safest drug to use in absence? ethosuximide
monotherapy for partial/primary generalized seizures topiramate
adjunct therapy fro refractory lennox-gastaut topiramate
MOA for topiramate voltage gated Na channels and glutamate receptor antagonist
SE topiramate kidney stones, cognitive defects, poor vision
adjunct for refractory adult partial seizures kepra
MOA for kepra SV2A protein in synaptic vesicle (binds to BOTOX)
used for refractory partial seizures neurontin
well tolerated drug usually used for neuropathic pain neurontin
do not use neurontin if patient is ___ bipolar
Created by: duanea00