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IBD SE

QuestionAnswer
arthralgia, dyspepsia, anemia sulfasalazine
increased LFTs, infectious complications, lymphoma azathioprine
hypertrichosis, hyperglycemia, hypertriglycerides, increased infection and lymphoma cyclosporin
interacts with cardiac glycosides and heparin sulfasalazine
decreased effectivity with antacids, PPI, H2 blockers mesalamine
increased bleeding risk with heparin (class) aminosalicyclates
take with food (2) sulfasalazine and ribavirin
supplement with folic acid sulfasalazine and methotrexate
BB warning for malignancy azathioprine
allopurinol increases risk for toxicity azathioprine
contraindicated with antibiotics, anti-convulsants, allopurinols, CCB, grapefruit juice, statins...CYP3A4 pathway cyclosporin
category X (2) methotrexate and cipro
primarily UC sulfasalazine
distal UC and mild-mod Crohns mesalamine
steroid sparing in IBD azathioprine
Crohns>UC for mod-severe maintenance methotrexate
severe refractory UC cyclosporin
mild-moderate Crohns, maintain UC remission budesonide
IBD that fails other treatments inflixamab
may cause infusion reaction, sepsis, serum sickness, TB reactivation inflixamab
BB for UC natalizumab
reactivates JCV natalizumab
used for refractory Crohns disease ustekinumab
causes pruritis, injection site erythema, increased malignancy risk ustekumab
don't use these 2 with other immune suppressants or vaccines natalizumab and ustekinumab
may cause tendon rupture cipro
do not use with warfarin (2) cipro and flagyl
alcohol intolerance flagyl
only used for crohns natalizumab
used for refractory crohns ustekinumab
1st generation ASA that interferes with prostaglandin synthesis sulfasalazine
inhibits dihydrofolate reductase-->death of T-lymphocytes methotrexate
calcineurin inhibitor, inhibits Tcell signal transduction cyclosporin
inhibits production of IL1, TNF and inflammation molecules budesonide
chimeric monoclonal antibody and anti-TNF infliximab
DNA gyrase inhibitor cipro
inhibits DNA synthesis, bactericidal metronizadole
aldehyde dehydrogenase inhibitor disulfiram
do not use for aerobic bacteria metronizadole
do not take with heparin aminosalicyclates
Created by: duanea00