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Fusion Inhibitors

Antiretroviral

QuestionAnswer
Fusion/Entry inhibitors Enfuvirtide, Maraviroc
blocks fusion of HIV receptors to bind to CD4/chemokine receptors (CCR5/CXCR4) on host cell Fusion/Entry Inhibitors
fusion inhibitor, only S.C., no cross-resistance, interferes w/gp41 (HIV fusion with host cell), no drug interactions, no CYP, resistance: mutation of HIV gp41 Enfuvirtide
CCR5/CXCR4 chemokine receptors necessary for entrance of HIV into CD4 cells; located on host cell
use only CCR5, fusion inhibitor, tropism tested first, decrease immunity, Maraviroc
gp41/gp120 receptors located on HIV virus
glycoprotein gp41 inhibited by what fusion inhibitor enfuvirtide
Created by: cburrows