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IBS/Hepatitis drugs
| Question | Answer |
|---|---|
| treats constipation, eliminates poisons | miralax |
| treats hepatic encephalopathy and constipation | lactulose |
| used for women with constipation IBS | amitiza |
| relieves short-term constipation IBS | zelnorm |
| women with diarrhea IBS | alosetron |
| relieves abdominal pain and bloating in pts w/o constipation | rifaximin |
| relieves abdominal pain due to smooth muscle relaxation and anti-cholinergic effects | dicyclomine |
| X with GI obstruction or appendicitis | miralax and amitiza |
| X with low galactose diet | lactulose |
| X crohns, UC, constipated patients | alosetron |
| don't use with other anticholinergics or during lactation | dicyclomine |
| must be taken BID q12 h | alosetron |
| dyspnea with first dose | amitiza |
| may cause electrolyte imbalances | miralax and lactulose |
| treats HBV | entecavir, adefovir, lamivudine |
| treats HCV | ribavirin |
| X in pregnancy (men too), anemia, ESRD | ribavirin |
| X lactation and kids<12 | adefovir |
| causes dose dependent hemolytic anemia | ribavirin |
| may cause exacerbation of hepatitis w/in 12 weeks of stopping med | adefovir |
| causes lactic acidosis, hepatic steatosis, pancreatitis, peripheral neuropathy | lamivudine |
| common SE is flu-like syndrome | interferons |
| HBV monotherapy and HCV +ribavirin | interferons |
| Xhepatic decompensation, autoimmune dz, hx of cardiac arrhythmias | interferons |
| interacts with psych meds and zidovudine | interferon alpha 2a |
| which interferon has a longer half life? | alpha 2a |
| BB lactic acidosis, hepatomegaly, steatosis | lamivudine |
| BB hep B exacerbation, HIV resistance, hepatomegaly | adefovir |
| BB hx of anemia | ribavirin |
| take with food | ribavirin |
| X acute HSV, vaccines, fungal infections | prednisolone |
| used for alcholic liver disease and alcoholic hepatitis | prednisolone |
| used in alcoholic hepatitis in pts who are not steroid candidates | pentoxifylline |
| non-steroidal phosphodiesterase inhibitor | pentoxifylline |
| may decrease mortality by decreasing hepatorenal syndrome | pentoxifylline |
| which anti-viral is CYP450 | ribavirin |