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GERD Drugs
| Question | Answer |
|---|---|
| which 2 classes of drugs block acid secretion | H2 blockers and PPI |
| weak bases that chemically neutralize acid | calcium carbonate |
| binds to mucosa and inhibits pepsin-catalyzed hydrolysis of mucosal proteins, ie builds up a protective wall | sulcrafate |
| prostaglandin that increases bicarb and mucus from epithelial cells, inhibits acid from parietal cells | misoprostol |
| locally acting, secretion reducing, topical that binds toxins and is anti-diarrheal | pepto |
| competitive antagonists at H2 receptors on parietal cells; inhibit meal secretions and basal secretions | H2 blockers |
| binds and irreversibly blocks ATP-dependent proton pump in parietal cell | PPI |
| which class+abx eliminates H. pylori | H2 blockers and PPI |
| relieves stress ulcers, ZE ulcers, GERD, dyspepsia, PUD | H2 blockers |
| PUD, GERD, ZE, may reduce gastric acid for 4-6 weeks | PPI |
| best 2 options for reducing acid in the elderly | ranitidine and calcium carbonate |
| PUD treatment in pts who cannot tolerate H2 or PPI | sulcrafate |
| prevents ulcers in pts taking NSAIDs | misoprostol |
| X varicella vaccine, MMRV, pts <20 w/flu, or if febrile | pepto |
| may cause Reye's syndrome | pepto |
| may cause early uterine contractions and not good w/CVD | misoprostol |
| requires acidic stomach for activation | sulcrafate and omeprazole |
| do not combine ___ with sulcrafate | antacids |
| AlOH causes____ | constipation |
| MgOH causes____ | diarrhea |
| Rolaids may increase the absorption of meds like ____ | Ldopa, weak bases |
| BB increased hip fractures in the elderly | PPI |
| interacts with atazanavir, antacids, and is CYP450 | omeprazole |
| first line agents to reduce gastric acid, suppress 90% acid | PPI |
| prokinetic agent | metoclopramide |
| anti-diarrheals | lomotil, immodium, pepto |
| stimulates smooth muscle in the GI, promotes ACh release and blocks DA | metoclopramide |
| bulk laxative that increases mass | psyllium |
| surfactant stool softener | colace |
| osmotic laxative | magnesium hydroxide and miralax |
| poorly absorbed molecules draw in water, increasing volume | magnesium hydroxide and miralax |
| preop for GI surgery | dulcolax |
| activates GI opiod receptors, decreases ACh release | lomotil and immodium |
| used for hypomotility, gastroparesis, intractable hiccup, antiemetic | metoclopramide |
| X seizures, GI obstruction, GI hemorrhage | metoclopramide |
| interacts with MAOI and may cause HTN crisis | metoclopramide |
| H2 blockers | ranitidine and famotidine |
| PPIs | omeprazole and esomeprazole |
| antacids | calcium carbonate |
| mucosal protective agents | sulcrafate, misoprostol, pepto |
| 5HT3 receptor antagonist, blocks afferent signals to CTZ | zofran |
| D2 blocker/anti-emetic and anti-psychotic | compazine |
| NK1 antagonist | emend |
| cannaboid receptor agonist | marinol |
| blocks vestibular component of vomit reflex | dramamine |
| anticholinergic, antiemetic, antidyskinetic | scopalamine |
| which 2 drugs are combined to treat chemo nausea | zofran+emend |
| chemo sickness and AIDS anorexia | marinol |
| motion sickness and parkinsons | scopalamine |
| which antiemetic has the most drug interactions? | compazine |
| a CYP450 and interacts with benzos | emend |
| stimulant laxative | dulcolax |
Created by:
duanea00
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