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Antibiotics 1


Antibiotic a molecule(synthetic or natural product) capable of SELECTIVELY inhibiting the GROWTH or SURVIVAL of one or more species of microorganisms at LOW concentrations.
MIC of an Antibiotic Minimum Inhibitory Concentration of the antibiotic which COMPLETELY PREVENTS the growth or survival of a microorganism in a standard assay. MIC VALUE measures POTENCY!
the Clinical Dose of an Antibiotic a dose of an antibiotic usually expected to achieve a plasma conc. of ~4-8X the MIC value of the antibiotic. must be associated with MINIMUM or NO toxicity to the patient.
Bacteriostatic Antibiotic an antibiotic which exhibits a bacteriostatic effect at the clinical dose.
Bactericidal Antibiotic an antibiotic which exhibits a bactericidal effect at the clinical dose.
The Bacteriostatic Effect when administered at the CLINICAL DOSE, it inhibits CELL DIVISION(growth) of the microorganism, allowing it to SURVIVE but STOP MULTIPLYING.
The Bacteriocidal Effect when administered at the CLINICAL DOSE, it inhibits SURVIVAL of the microorganism(kills it).
Narrow-Spectrum Antibiotic antibiotic effective only against a LIMITED number of bacterial species/strains. (use of these contributes significantly to minimizing the emergence of microbial resistance to antibiotic therapy).
Broad-Spectrum Antibiotic antibiotic effective against a large number of bacterial species/strains, which would usually include both Gram+ and Gram- bacterial. Should ONLY be used when ABSOLUTELY NECESSARY b/c they contribute more to emergence of microbial resistance.
Created by: 11820778