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Adrenoceptors L11
PHAR2002 Term 1 Drugs Adrenoceptors L11
Term | Definition |
---|---|
Adrenoceptors are what type of receptors? | GPCR |
Order of Potency: Alpha-adrenoceptors | Adrenaline > Noradrenaline > Isoprenaline (ANI) |
Order of Potency: Beta1-adrenoceptors | Isoprenaline > Adrenaline > Noradrenaline (IAN) |
Order of Potency: Beta2-adrenoceptors | Isoprenaline > Noradrenaline > Adrenaline (INA) |
Most alpha1 are ... Most alpha2 are ... | Postsynaptic, Presynaptic |
AGONIST Activates alpha and beta (but more strongly for alpha) | Noradrenaline |
AGONIST Activates alpha and beta (but more strongly for beta) | Adrenaline |
AGONIST Beta1 and Beta2 Selective | Isoprenaline |
AGONIST Alpha1 Selective | Phenylephrine |
AGONIST Alpha2 Selective | Clonidine |
AGONIST Alpha Selective (but more strongly for alpha2) | alpha-methyl noradrenaline |
AGONIST Beta Selective (but more strongly for beta2) | Salbutamol |
ANTAGONIST Alpha Selective | Phentolamine, Phenoxybenzamine |
ANTAGONIST Alpha Selective (but more strongly for alpha1) | Prazosin |
ANTAGONIST Beta Selective | Propranolol |
ANTAGONIST Beta Selective (but more strongly for beta1) | Atenolol |
Adrenaline at LOW conc. resembles | Isoprenaline |
Adrenaline at HIGH conc. resembles | Noradrenaline |
Partial Agonist Alpha2 Selective | Clonidine |
Partial Agonist Beta Selective | Oxprenolol |