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Adrenoceptors L11

PHAR2002 Term 1 Drugs Adrenoceptors L11

Adrenoceptors are what type of receptors? GPCR
Order of Potency: Alpha-adrenoceptors Adrenaline > Noradrenaline > Isoprenaline (ANI)
Order of Potency: Beta1-adrenoceptors Isoprenaline > Adrenaline > Noradrenaline (IAN)
Order of Potency: Beta2-adrenoceptors Isoprenaline > Noradrenaline > Adrenaline (INA)
Most alpha1 are ... Most alpha2 are ... Postsynaptic, Presynaptic
AGONIST Activates alpha and beta (but more strongly for alpha) Noradrenaline
AGONIST Activates alpha and beta (but more strongly for beta) Adrenaline
AGONIST Beta1 and Beta2 Selective Isoprenaline
AGONIST Alpha1 Selective Phenylephrine
AGONIST Alpha2 Selective Clonidine
AGONIST Alpha Selective (but more strongly for alpha2) alpha-methyl noradrenaline
AGONIST Beta Selective (but more strongly for beta2) Salbutamol
ANTAGONIST Alpha Selective Phentolamine, Phenoxybenzamine
ANTAGONIST Alpha Selective (but more strongly for alpha1) Prazosin
ANTAGONIST Beta Selective Propranolol
ANTAGONIST Beta Selective (but more strongly for beta1) Atenolol
Adrenaline at LOW conc. resembles Isoprenaline
Adrenaline at HIGH conc. resembles Noradrenaline
Partial Agonist Alpha2 Selective Clonidine
Partial Agonist Beta Selective Oxprenolol
Created by: zccayxc



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