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PHAR2002 Term 1
PHAR2002 Term 1 Drugs
Term | Definition |
---|---|
Excitatory NANC | ATP, Substance P |
Inhibitory NANC | Neurotensin, VIP |
Muscarinic ACh receptors are antagonized by ... and produced by ... doses of ACh | Atropine, Low |
Nicotinic ACh receptors are antagonized by ... and produced by ... doses of ACh | Tubocurarine, High |
Adrenaline release from Adrenal Medulla blocked by | Hexamethonium |
Muscarinic Agonists | ACh, Methacholine, Carbachol, Pilocarpine |
Muscarinic Antagonists | Atropine, Hyoscine (Scopolamine), Homatrophine All tertiary bases --> enter brain easily |
Ganglion-blocking Drugs | Hexamethonium (no longer used, too many side effects), Trimetaphan (controlled hypotension during surgery) |
Neuromuscular Blocking Drugs | Hemicholinium (inhibits reuptake of ACh), Botulinium toxin (blocks release of ACh at NMJ), Streptomycin (inhibits ACh by blocking Ca entry) |
Clinically Useful NM Blocking Agents | Pancuronium/Atracurium (competitive blocks, Myastenia Gravis sensitive), Suxamethonium (depolarizing block) |
Types of Cholinesterases (ChE) | Acetylcholinesterase (ChE), Butyrylcholinesterase |
ChE Inhibitors | Slow-acting: Erdophonium Medium-Long/Reversible: Neostigmine, Eserine Long/Irreversible: Dyflos, Organophosphates |
ChE Reactivators (for Organophosphate poisoning) | Pralidoxime |
Bile acid binding Resins, Fibrates, Niacin, Inhibitors of Cholesterol from Gut | Cholestyramine, Fenofibrate, Nicotinic acid, Ezetimibe |
Inflammatory Mediators for Heat/Redness | Histamine, NO, Bradykinin |
Inflammatory Mediators for Swelling | Histamine, PAF, Bradykinin |
Inflammatory Mediators for Pain | Substance P, Calcitonin-gene related peptide, Bradykinin |
Inflammatory Mediators for Loss of Function | Lipases, Proteases, Free radicals |
Histamine Equation | Histidine --(Histidine Carboxylase)--> Histamine |
Metabolism of Histamine | Oxidation - Diamine oxidase (histaminase) N-methylation - N-methyltransferase Acetylation - Gut flora |
Bradykinin Equation | Kininogens --> Kallidin --(Aminopeptidase)--> Bradykinin |
Platelet-Activating Factor (PAF) Equation | Acly-PAF --(PLA2)--> lysoPAF --(Acetylation)-->PAF |
Cytokines | Interleukins, Tumor necrosis factors, Interferons |
H1 Agonist | 2-methyl histamine |
H1 Antagonist that CROSS BBB | Diphenhydramine, Chlopheniramine |
H1 Antagonist that DO NOT CROSS BBB | Astemizole, Terfenadin, Cetirizine |
H2 Agonist | 4-methyl histamine, Dimaprit, Impromidine |
H2 Antagonist | Cimetidine, Ranitidine |
Peptic Ulcers: Proton pump inhibitors | Omeprazole |
Peptic Ulcers: Antacids | Aluminum hydroxide, Magnesium bicarbonate |
Peptic Ulcers: Coating agents | Sucralfate |
Peptic Ulcers: Anticholinergic agents | Dicyclomine |
2 Metabolic Pathways for Arachidonic Acid | Arach Acid --(5'-lipoxygenase + FLAP)--> HPETE Arach Acid --(Cyclooxygenase)--> PGG2 |
Eicosanoid Equation | Phospholipid --(Phospholipase A)--> Arachidonate --(Cyclooxygenase)--> Cyclic-endoperoxidases --> PGI2 / TXA2 |
Anti-inflammatory Drugs | Prednisolone, Betamethasone |
NSAIDs (COX-1 Non-selective inhibitor) | Aspirin, Oxyphenbutazone, Paracetamol, Indomethacin, Meclofenamic acid, Ibuprofen, Naproxen |
NSAIDs COX-2 Selective inhibitor | Celecoxib |
Overdose of Aspirin | Forced Alkaline Diuresis |
Overdose of Paracetamol | Methionine |
Overdose of Indomethacin | Anti-TNFα |