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Pharmacology
CARDIOVASCULAR & RENAL SYSTEMS Antilipemic agents
| Question | Answer |
|---|---|
| Antilipemic agents treat conditions associated with excess _____ in the ____ stream. | cholesterol in the blood stream |
| What are the four types of lipids? | 1.Chylomicrons 2. Very low density lipoproteins [VLDL] 3. Low density lipoprotein [LDL] 4. High density lipoprotein [HD |
| What are the two primary forms of lipids in the blood? | triglycerides & cholesterol |
| _____ are an energy source, & are stored in _____tissue | Triglycerides; adipose |
| Cholesterol is primarily used to make ______cell membranes, & _______. | steroid hormones, bile acid |
| Where does lipid metabolism occur? | Liver |
| Antilipemic drugs are used to _____ high levels of ____within blood | lower; lipids |
| How do you treat high cholesterol? | Drugs Life Style Changes |
| What are the major antilipemic drugs? | 1. HMG-CoA reductase inhibitors 2.Bile acid sequestrates 3. Niacin 4. Fibric acid derivatives 5. Cholesterol absorption inhibitor (Zetia) |
| HMG-CoA Reductase Inhibitors are also known as ____ | Statins |
| HMG-CoA Reductase Inhibitors _____HMG-CoA enzyme to _____cholesterol concentration in the blood stream, which (↓cholesterol production) | Inhibit ; decrease |
| Atorvastatin (Lipitor) is a | HMG-CoA Reductase Inhibitors |
| What are the side effects of Lipitor and HMG-CoA reductase inhibitors? | GI disturbance, ↑ liver enzyme levels |
| Bile Acid Sequestrants are released in ___ | intestine |
| Bile Acid Sequestrants allows the ___ to releases cholesterol to bind to bile acids | liver |
| BIle Acid Sequestrant binding to the liver leads to____absorption in intestine (↓cholesterol absorption) | decreasing |
| Cholestyramine (Questran is a _____. | Bile Acid Sequestrant |
| Fibric Acid Derivatives are a class of medication that ______ triglyceride levels. | re a class of medication that lowers blood triglyceride levels. |
| emfibrozil & clofibrate synthesis of ____ | VLDL |
| What is the most common side effects for Fibric Acid Derivatives? | GI irritation |
| is effective intreating in most _____ | hyperlipidemias |
| There are a few patients that can tolerate ________ . | Nicotinic acid /niacin/vitamin B3 |
| If Patient experiences flushing, itching, peptic ulcer, diabetic intolerance you should ____ use. | Discontinue use |
| What are side effects for antilipemics that you should teach your patient to notice? | 1.Muscle pain, 2.other unexplained pain 3. GI upset, constipation 4. Yellow discoloration of skin 5. Decreased sex drive |
| Regarding antilipmic agents you must monitor ____ and ___ functions. | Monitor liver and renal function |
| You should monitor _____ function when taking antilipemic agents. | Monitor cholesterol level |
| You must give antilipemic meds during _____ meal time with ___ of water. | evening; 120 to 180 ml of water |
| You should not ____ antilipemic pills. | crush |
| When on antilipemic pills you should drink__ ml of water a day. | Drink at least 2000 ml water each day |
Created by:
jwhite223
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