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Geriatrics

QuestionAnswer
changes in PK decrease absorption of various drugs secondary to decrease in stomach acidity, decease TBW, increase lipid storage, decrease albumin, decrease hepatic blood flow and reduced hepatic enzyme activity, decreased renal blood flow and decreased GFR
drugs that cause psychiatric symptoms anticholinergics, narcotics, TCAs, CNS stimulants, anti-parkinson's
drug that produce anxiety symptoms theophylline, nasal decongestants, beta agonists, antiparkinsons, appetite suppressants
drugs that contribute to nutritional deficiency diuretics, digoxin, digitalis, laxatives (overuse), sedatives (overuse)
drugs at risk with elderly long-acting BZD-Librium, Valium, elavil, digoxin, mepiridine, antipsychotics
drugs that can worsen alzheimers antidepressants, antiparkinsonian, antipsychotics, antispasmodics, antihistamines, antiemetic
symptomatic therapy BZDs-lorazepam, oxazepam, buspirone; Antidepressants - sertraline or citalopram; Antipsycotics - haldol, risperdal, abilify; sedative hypnotics - trazodone, ambien, temazepam
tacrine cognex; anticholinesterase inhibitor; potential hepatotoxicity
donepezil aricept; anticholinesterase inhibitor
rivastigmine exelon; anticholinesterase inhibitor
galantamine razadyne; anticholinesterase inhibitor
Namenda Memantadine; NMDA receptor antagonist
drugs used to treat PD carbidopa-levadop, bromocriptine, pergolide, pramipexole, ropinorole, seligilie, entacapone, tolcapone, amantadine, benztropine, trihexylphenidyl, carbidopa/levodopa/entacapone
carbidopa-levodopa Sinemet
Bromocriptine Parlodel; dopaminergic
Pergolide Permex; dopaminergic
Pramipexole Mirapex; dopaminergic
Ropinrole Requip; dopaminergic
Selegiline Eldepryl; Carbex; Ataprl, Selpak; MAOB inhibitor
Entacapone Comtan; COMT inhibitor
Tolcapone Tasmar; COMT inhibitor
Amantadine Symmetrel
Benztropine Cogentin; anticholinergic
Trihexylphenidyl Artane; anticholinergic
Carbidopa/Levadopa/Entacapone Stalevo
dopaminergics ADRs N/V, agitation, confusion, depression, psychoses, orthostatic hypotension, dyskinetic movements
selegiline ADRs N/V, insomnia, dizziness, agitation, confusion, dyskinetic movements, anorexia
Amantadine ADRs confusion, dizziness, depression, anxiety, psychoses, insomnia
COMT inhbitors ADRs N/V, diarrhea, dyskinesia, urine coloration, liver toxicity
sinemet mechanism levadopa increases DA; carbidopa prevents metabolism
glaucoma treatment beta blockers, carbonic anhydrase inhibitors, prostaglandin analogs, alpha agonists
ophthalmic beta blockers ADRs adverse cardiac effects, worsening of pulmonary disease, depression, dizziness
timolol timoptic; beta blocker
carteolol ocupres; beta blocker
Levobunolol Betagen; beta blockers
metipronolol optipranolol; beta blocker
betaxolol betoptic; beta blocker
levobetaxolol betaxon; beta blocker
carbonic anhydrase inhibitors lethargy, decrease appetite, GI upset, urinary frequency
Acetazolamide Diamox; carbonic anhydrase inhibitor
dorzalamide trusopt; carb anhydrase inhibitor
brinzolamide azopt; carb anhydrase inhibitor
methazolamide neptazone; carb anhydrase inhibitor
latanoprost xalatan; prostaglandin analog
prostaglandin analog ADRs iris pigmentation, darkens eyelid, macular edema
bimatoprost lumigan; prostaglandin analog
travaprost travatan; prostaglandin analog
unoprostone rescular; prost analog
alpha agonist ADRs tachycardia, dry mouth, eyelid elevation, CNS effects
brimonidine alphagan; alpha agonist
dipivefrin propine; alpha agonist
pilocarpine pilocar; alpha agonist
acetazolamide DDIs phenytoin, lithium, aspirin, cyclosporine
Cosopt timolol+dorzolamide
Created by: cytoskeletor
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