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Major Depression

QuestionAnswer
TCA's mechanism increase in NE and 5HT
TCA ADRs orthostatic hypotension, tachycardia, sedation, anticholinergic, QT prolongation, weight gain, sexual dysfunction, tertiary amines (amitryptiline, doxepin, imipramine, clomipramine) has more side effects than secondary amines (nortriptyline and desipramin
Amitriptyline Elavil
Nortriptyline Aventyl, Pamelor
Imipramine Tofranil
Doxepin Sinequan
Clomipramine Anafranil
Desipramine Norpramin
MAOI's MOA increase 5HT, DA, NE
MAOI ADRs orthostatic hypotension, weight gain, sexual dysfunction, antcholinergic, hypertensive crisis
MAOI CI renal dysfunction; PSE, fluoxetine (5 weeks); SSRIs (2 weeks)
Venlafaxine ADR GI upset (XR minimizes), anxiety, insomnia, HA, BP elevation
Serotonin syndrome augmented by these drugs sibutramine, triptans, tramadol, trazodone
Duloxetine MOA 5HT and NE
Duloxetine CI narrow angle glaucoma
Duloxetine ADR GI upset, dry mouth, dizziness, decreased appetite, increase BP, urinary hesitation
Trazodone ADR Deseryl; extremely sedating, orthostatic hypotension, priaprism
Nefazodone ADR Serzone; GI upset, sedation, dry mouth, constipation, light headedness
Nefazodone BBW hepatotoxicity
Tranylcypropramine Parnate; MAOI
Phenelzine Nardil; MAOI
Mirtazapine ADR sedation, increase appetite, weight gain, constipation, increase LFTs, increase TG; agranulocytosis, neutropenia
selegiline (ensam) patches ensame; MAOI; causes headache, insomnia, application site reactions, diarrhea, dry mouth
Created by: cytoskeletor
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