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Schizophrenia

QuestionAnswer
types of schizophrenia paranoid, disorganized, catatonic, residual
clinical presentation hallucinations, delusions, disorganized speech/thoughts/behaviors, impaired cognition attention concentration judgment, anhedonia, flat affect, avolition
typical antipyschotics chlorpromazine, thioridazine, fluphenazine, haloperidol, perphenazine, loxapine
chlorpromazine thorazine
thiordazine mellaril
haloperidol haldol
fluphenazine prolixin
ADR sedation, orthostasis, weight gain, anticholinergic, EPS, dystonic reactions, akathisia, pseudoparkinsonism, tardive dyskinesia, NMS, decrease prolactin, decrease glucose tolerance, photosensitivity, hypothalamic effects, QT prolong, pigmentary retinopath
treating dystonic reactions benztropine and diphenhydramine
treating pseudoparkinsonism amantadine
treating tardive dyskinesia lower dose of drug, vit B6 and vit E
neuroleptic malignant syndrome symptoms rapid progression (<24 hrs), body temp <104, lead pipe rigidity, HTN, diaphoresis, increase HR, incontinence, increase LFTs CPK WBCs
treating NMS bromocriptine (dopamine agonist) and dantrolene (smooth muscle relaxant)
low potency antipsychotics cause more... sedation, weight gain, orthostasis, anticholinergic
high potency antipsychotics causes more EPS
low potency antipsychotics thioridazine, chlorpromazine
high potency antipsychotics haloperidol, fluphenazine
atypical antipsychotics less severe side effects, more weight gain lipid abnormalities risk of diabetes, decrease risk for D2 receptors, BBW about atypicals and elderly
Clozapine ADR Clozaril; sedation, weight gain, hypersalivation, seizure risk, agranulocytosis
Risperidone Risperdal; dose related EPS, maybe weight gain, maybe sedation, prolactin elevation, orthostasis
Olanzapine Zyprexa; sedation, orthostasis, weight gain
Quetiapine Seroquel; low EPS and prolactin elevation risk
Ziprasidone Geodon; maybe sedation, maybe weight gain; QT prolongation
Aripriprazole Abilify; possible insomnia, maybe weight gain
Paliperidone Invega; headache, tachycardia, somnolence, anxiety
Haldol deconoate IM every 4 weeks
Fluphenazine deconoate Prolixin D; IM every 2 weeks
Risperidone injection Consta; must overlap with PO x 3 weeks; reaches steady state in 8 weeks; injection every 3 weeks
Created by: cytoskeletor
Popular Pharmacology sets

 

 



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