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Oncology
| Question | Answer |
|---|---|
| TNM Staging | Stages O - IV; T=size of tumor; N=extent of lymph node involvement; M= presence or absence of metastases |
| Cure | 5 years of cancer free survival |
| Complete response | absence of all neoplastic disease for at least one month after cessation of treatment |
| Partial Response | >50% decrease in tumor size for at least one month |
| Stable Disease | no change or criteria for PR progression not met |
| progression | >24% increase in tumor size |
| Alkylating Agents | Non-phase specific; Cyclophosphamide, Ifosphamide, Carmustine, Dacarbazine, Temozolamide, Meclorethamine, Melphelan, Chlorambucil, Busulfan, Streptozosin |
| Alkylating Agents ADRs | myelosuppression esp leukemia, mucus ulcers, pulmonary fibrosis (carmustine), interstitial pneumonitis, alopecia, N/V, amenorrhea, azoospermia, hemorrhagic cystitis (I and C), encephalopathy with I, seizures |
| Antimetabolites | S Phase specific; permitrexed, MTX, azacitidine, 5-FU, cytarabine, capecitabine, mercaptopurine, thioguanine, fludarabine |
| ADRs of antimetabolites | hand-foot syndrome (5-FU and Capecitabine); severe diarrhea, GI mucosal damage, NV, fatigue, myelosuppression, alopecia, neurotoxicity, rash and fever, flu like sx, renal tox and mucositis (5-fU MTX), conjunctivitis, hemolytic uremic syndrome; opportunist |
| Anti-tumor Abx | inhibit topo II; Doxorubicin, Daunarubicin, Epirubicin, Idarubicin, Mitoxantrone, Mitomycin, Bleomycin |
| ADRs | severe N/V, alopecia, stomatitis |
| anthracyclines ADRs | cardiac toxicity, AML, avoid in patients with cardiac history |
| bleomycin ADRs | pulmonary fibrosis and interstitial pneumonitis |
| lifetime dose of doxorubicin | 450-500 taking into account of other antras recieved |
| lifetime dose of epirubicin | 900 |
| Hormone and antagonists | aminoglutethimide, megestrol, medroxyprogesterone, ethinyl estradiol, tamoxifen, fulvenstrant, toremifene, exemestane, anastrazole, letrozole, testosterone, fluoxymegestrone, bicalutamide, nilutamide, triptorelin, leuprolide, goserelin, abarelix |
| hormones ADRs | edema, menstrual disorder, hot flashes, transiet muscle or bone pain, tumor flare, transient increase in LHRH, gynecomastia, elevated liver enzymes, N/V, diarrhea, erectile impotence, decreased libido, endometrial cancer w/ tamoxifen; bone loss, vent arrh |
| Plant alkaloids | Docetaxel, paclitaxel, etoposide, teniposide, irinotecan, topotecan, vincristine, vinblastine, vinorelbine |
| Plant ADRs | myelosuppression, mucositis, N/V, alopecia, edema (docetaxel), hypotension/hypersensitivity upon admin (paclitaxel), neurotoxicity (vincristine), diarrhea, HA, SIADH (vincas) |
| Biologicals and MABs | aldesleukin, thalidomide, lenalidomide, rituxan, trastuzumab, gemtuzumab, alemtuzumab, bevacizumab, cetuximab |
| Biologicals ADRs | hypotension, hypersensitivity to infusion, cardiac, pulmonary, renal impairment, avoid in autoimmune disorders, mental status changes, fever, chills, nausea, musculoskeletal pain, tumor lysis syndrome with rituximab |
| thalidomide ADRs | neurotoxicity, neutropenia, DVT |
| premedicate for MABs | APAP and benadryl |
| Platinum compounds | cisplatin, carboplatin, oxaliplatin |
| PLatinum ADRs | nephrotoxicity, peripheral neurotoxicity, myelosuppression, ototoxicity, N/V |
| Renal & Urinary Dysfunction | CIMS-C; Cyclophosphamide, Ifosphamide, MTX, Streptozocin, Cisplatin; premedication with hydration therapy, mannitol |
| Hepatitis | (Cytara Did Make Mitch's Night Tonight) Cytarabine, Daunarubicin, MTX, Mercaptopurine, Nitrosurea, Thioguanine |
| Cardiotoxicity | Anthracyclines (includes Mitoxantrone); limit cumulative doses |
| Extravasation | (Anthony Might Visit Mr. Pacman); Anthrocyclines, Mitomycin, Vincas, Mechlorethamine, Paclitaxel; give cold compresses and NS |
| Neurotoxicity | (PAMCCV); Paclitaxel, Aspariginase, MTX, Cisplatin, Cytarabine, Vinchristine |
| Photosensitivity | Actinomycin, 5FU, MTX |
| Infertility | (Cindy's Mom Might Come); Cyclophosphamide, Melphelan, Mechlorethamine, Chlorambucil |
| Hypersensitivity | (Paul Asked Connie To Eat Chinese); Paclitaxel, Aspariginase, Cisplatin, Teniposide, Etoposide, Carboplatin; premed with Ranitidine/Cimetidine, diphen, dex |
| Hepatotoxicity | (Anthony Could Marry Meth); Asparaginase, Cytarabine, Mercaptopurine, Methotrexate |
| Alopecia | (Cory Does Pay Mike); Cyclophosphamide, Doxorubicin, Paclitaxel, Mechlorethamine |
| N/V | (CCC-DI-MMM) Cisplatin, Cyclophosphamide, Cytarabine, Dacarbazine, Ifosphamide, Melphelan, Mechlorethamine, Mitomycin |
| Myelosuppression | (Al Forgot Mary's Coming Late); Alkylating agents, Fluorouracil, MTX, Cyclophosphamide, Lomustine; treat with GCSF, platelet infusions, EPO |
| Diarrhea | Irinotecan, 5-FU; give atropine as pre-med, treat with lopramide |
| Renal toxicity | (CIMS); Cisplatin, Ifosphamide, MTX, Streptozocin |
| Pulmonary toxicity | BB-MC; bleomycin, busulfan,carmustine, mitomycin; treat with Corticosteroids |
| Ileus | Vincristine, Vinblastine |
| Edema | Docetaxel; prophylax with dexamethasone |
| Neuropathy | (PMV) Plant Alkaloids, MTX, Vincas |
| Stomatitis | 5-FU, MTX, Daunorubicin; hold ice chips in mouth, palifermin |
Created by:
cytoskeletor
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