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Hyperthyroidism
| Question | Answer |
|---|---|
| PTU | propylthiouracil |
| Tapazole | Methimazole |
| Lugol's solution | Strong iodine solution |
| SSKI | Saturated solution of potassium iodide |
| Hyperthyroidism types | Grave's disease, toxic multinodular goiter (MNG), toxic adenoma, and exogenous thyroid hormone |
| Drugs that cause hyperthyroidism | amiodarone and iodine |
| three primary methods for controlling hyperthyroidism | surgery, radioactive iodine (RAI), and antithyroid (thionamide) drugs |
| What drug is preferred in pregnancy? | PTU; RAI is contraindicated |
| adjunctive treatment for hyperthyroidism | beta blockers and CCB's to control tachycardia |
| ADRs of thionamides | fever, headache, paresthesias, rash, arthralgia, urticaria, jaundice, hepatitis, agranulocytosis, leukopenia, bleeding |
| DDIs | potentiates warfarin effects |
| Iodides ADRs | rash, swelling of salivary glands, metallic taste, burning of mouth, GI distress, hypersensitivity, goiter |
| Iodidies DDI's | lithium potentiates antithyroid effects of iodides |