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Prokinetics: GI stimulants, stimulate motility without stimulating gastric, biliary, or pancreatic secretions metoclopramide[Reglan]
sensitizes tissues to the action of acetylcholine
increased the tone and amplitude of gastric contractions, relaxes the pyloric sphincter and duodenal bulb, increases peristalsis resulting in accelerated gastric emptying and increased speed of gastric transit
almost no effect on the colon and gallbladder
in GERD can help by increasing the lower esophageal sphincter pressure
induces release of prolactin and transient increases circulation aldosterone levels, which can cause galactorrhea, amenorrhea gynecomastia, impotence [d/t increased prolactin], and fluid retention[increased aldosterone]
antiemetic properties d/t its antagonism of central and peripheral dopamine receptors
black box warning r/t risk of developing tardive dyskinesia
tx should not exceed how long 12 weeks except in rare cases
contraindicated in gi hemorrhage, mechanical obstruction, new gi surgery, perforation
can be used in children unless the child has a seizure disorder
clinical uses GERD, diabetic gastroparesis
Created by: heatherbrown2020



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