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Prokinetics
| Question | Answer |
|---|---|
| Prokinetics: GI stimulants, stimulate motility without stimulating gastric, biliary, or pancreatic secretions | metoclopramide[Reglan] |
| sensitizes tissues to the action of | acetylcholine |
| increased the tone and amplitude of gastric contractions, relaxes the pyloric sphincter and duodenal bulb, increases peristalsis resulting in | accelerated gastric emptying and increased speed of gastric transit |
| almost no effect on the | colon and gallbladder |
| in GERD can help by increasing the | lower esophageal sphincter pressure |
| induces release of prolactin and transient increases circulation | aldosterone levels, which can cause galactorrhea, amenorrhea gynecomastia, impotence [d/t increased prolactin], and fluid retention[increased aldosterone] |
| antiemetic properties d/t | its antagonism of central and peripheral dopamine receptors |
| black box warning r/t | risk of developing tardive dyskinesia |
| tx should not exceed how long | 12 weeks except in rare cases |
| contraindicated in | gi hemorrhage, mechanical obstruction, new gi surgery, perforation |
| can be used in children unless the child has | a seizure disorder |
| clinical uses | GERD, diabetic gastroparesis |
Created by:
heatherbrown2020
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