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Cytoprotective Agent

Carafate is a basic aluminum salt that covers the ulcer site and acts as a barrier to acid, pepsin and bile salts, little is absorbed, bay directly absorb vile salts and stimulate endogenous prostaglandin synthesis
Misoprostol is a methyl analogue of prostaglandin E1 inhibition of gastric secretion through ingibition of histamine-stimulated cAMP[cyclic adenosine monophosphate]
Misoprostol is pregnancy category X, produces uterine contractions, may cause abortion, birth defects, uterine rupture
Misoprostol common ADR diarrhea, 13-40%
clinical usage is tx and prophylaxis of duodenal ulcers associated with NSAID use[Misoprostol] or tx of duodenal ulcers from other causes[Carafate]
Created by: heatherbrown2020



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