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Cytoprotective Agent
Question | Answer |
---|---|
Carafate is a basic aluminum salt that | covers the ulcer site and acts as a barrier to acid, pepsin and bile salts, little is absorbed, bay directly absorb vile salts and stimulate endogenous prostaglandin synthesis |
Misoprostol is a methyl analogue of prostaglandin E1 | inhibition of gastric secretion through ingibition of histamine-stimulated cAMP[cyclic adenosine monophosphate] |
Misoprostol is pregnancy category | X, produces uterine contractions, may cause abortion, birth defects, uterine rupture |
Misoprostol common ADR | diarrhea, 13-40% |
clinical usage is | tx and prophylaxis of duodenal ulcers associated with NSAID use[Misoprostol] or tx of duodenal ulcers from other causes[Carafate] |