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H2 Blockers

QuestionAnswer
Gastric parietal cells have 3 receptors that can be stimulated to cause the parietal cell to produce H+: 1. acetylcholine 2. gastrin 3. histamine 2
H2Bs are highly selective and do not block H1 receptors and are not anticholinergic
B/c they do not inhibit acetylcholine they reduce gastric acid by only 35-50%
H2Bs that have no effect on gastric emptying: Tagamet, Zantac, Pepcid
H2Bs that have no effect on LES pressure: Tagamet, Pepcid
H2Bs that have little or no effect on fasting or postprandial serum gastrin: Zantac, Axid, Pepcid
H2B that does not affect pepsin secretion or pentagastrin-stimulated intrinsic factor secretion Zantac
Precautions with impaired renal function Tagamet has the most problem, Zantac the least
H2B that should not be used with hepatic disease Axid, Zantac
May be used in infants and children Zantac, Pepcid
Created by: heatherbrown2020
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