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Renal Drugs

Chlorothiazide (Diuril) Hydrochlorothiazide (HydroDIURIL) Chlorthalidone (Thalitone) ↓ Na+ Cl reabsorption, also lose K+. Thiazide Diuretics. Patients are at risk for hypokalemia
Furosemide (Lasix) ↓ Na+ Cl reabsorption, high K+ loss also. Much more potent than Thiazides. Works in the loop. Increase sodium loss.
Bumetanide (Bumex) Most potent in the loop.
Amiloride (Midamor) ↑ Na+ excretion, ↓ K+ secretion Hyperkalemia
Mannitol (Resectisol) ↓ Na + H20 reabsorption osmotically
Thiazides HTN, mild CHF, edema. Causes hypokalemia, hyperuricemia, Hyperglycemia, hypercalcemia, hypomagnesemia.  Fluid loss = hypotension. *↑ toxic reactions to digoxin and lithium. Take early in the morning. Eat bananas, anything with K.
Loop diuretics CHF, renal disease, HT crises Cause marked hypokalemia, hyperuricemia, hyperglycemia, hypocalcemia, hypomagnesmia.  *Ototoxicity occurs w/ethacrynic acid and furosemide (damages hair cells) - occurs esp. w/IV use and rapid infusion.K supplement!
Potassium - sparing Used in combination w/other diuretics (esp. thiazides) to treat HTN. Hyperkalemia!  Sprinolactone - used for hyperaldosteronism; may cause endocrine imbalances. Triamterine/Amiloride- hyperkalemia is worse. may turn urine blue! mean get female traits.
Osmotic Diuretics (mannitol) Renal failure, ↑ drug excretion, ↓ ICP or IOP, ↓ nephrotox of cisplatin. Causes headache, NVD.  Give only IV.  May ↑ venous BP initially + could induce heart failure.
Created by: whitneydpugh



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