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Pharm 5, and 6
sympathetic and parasympathetic
Question | Answer |
---|---|
PNS is composed of 12 pairs of cranial and how many pairs of spinal nerves? | 31 pairs of spinal nerves |
PNS contains what type of nerves? | Both somatic and visceral nerves. |
What is the Somatic division? | Cranial and spinal nerves that innervate skeletal muscle. |
What are skeletal nerves classified as? | Voluntary; they are under conscious control. |
What is another name for the ANS? | visceral division |
What type of muscles do the autonomic nerves innervate? | Cardiac and smooth muscle found in visceral organs and glands. |
The visceral division is divided into what 2 divisions? | parasympathetic and sympathetic |
When is the sympathetic division more active? | during periods of increased energy expenditure and stress. |
What neurotransmitter do the sympathetic nerves release? | Norepinephrine at the post ganglionic site. |
What is a neurotransmitter? | Chemical messengers |
What are the receptor sites that accept NE and EP called? | adrenergic receptor sites. |
What are some of the functions of NE (Norepinephrine)? | Affects cardiovascular system ^ HR, ^BP, cognition, thinking process ability to make decisions, arousal, ability to wake, to be awakened |
What happens when NE levels are high? | anxiety, schizophrenia, manias. |
What happens when NE levels are low? | depression |
When is the parasympathetic division more active? | During rest, digestion and elimination of waste products |
What neurotramistter is released by the parasympathetic nerves? | acetylcholine or ACH. |
What are the receptor sites that accept ACH called? | cholinergic receptor sites. |
Some of the functions of ACH are: | affects sleep, arousal, ability to feel pain, movement (motor), memory |
What happens when Ach levels are high? | Depression. |
What happens when Ach levels are low? | Parkinson’s disease. |
What are some effects of SNS? | Vasoconstriction of arteries, ^ HR, increased contractile of the heart, decreased GI motility and secretions; dilated pupils, bronchodilation, urinary bladder relaxation, urinary sphincter contraction. |
The main neurotransmitters of SNS are | NE and EPI. |
List the differences between NE and EPI | NE – will not activate beta 2 receptors sites, and EPI – will stimulate alpha, Berta 1, Beta 2 receptor sites. |
What neurotransmitters will adrenergic receptors accept? | NE and EPI. |
Adrenergic receptors are classified as what? | alpha-adrenergic or beta-adrenergic. |
Where are Alpha-adrenergic receptors found? | mainly on smooth muscle membranes (blood vessels). |
Where are Beta-adrenergic receptors found? | on smooth (Beta-2) and cardiac (Beta-1) muscle membranes. |
What are the 2 main classes of drugs that affect the SNS? | sympathomimetics and sympatholytics. |
What is the difference between the sympathomimetics, and sympatholytics? | Sympathomimetics (mimic) produce effects that are similar to stimulating of the SNS, Sympatholytics block the actions of the SNS. |
How are sympatholytics classified? | as either alpha-adrenergic blocking drugs or beta-adrenergic blocking drugs. |
Alpha blockers compete with what? | NE for the binding to the alpha-adrenergic receptors. |
What does NE normally do to adrenergic receptors? | Activates the adrenergic receptors (produce sympathetic response) by constructing smooth muscle. |
What are alpha blockers used for? | to treat hypertension. |
What are some adverse effects of alpha blockers? | Dizziness, confusion, lethargic, N/V, |
MOA of sympathomimetics | produce effects that are similar to simulating the SNS. |
The Beta blockers are used for what condition? | hypertension by decreasing the rate, force of contraction and impulse conduction of the heart. |
What are the beta blockers divided into? | nonselective beta-blockers and selective beta-blockers. |
What is the difference between non-selective beta blockers and selective beta-1 blockers? | Non-selective block Beta 1 and Betat 2 receptors, whereas, selective Beta only targets betat 1. |
Are there any specific therapeutic indications for blocking the beta-2 receptors? | No. |
What are some adverse effects of beta blockers? | N/V, bradycardia, CHF, cardiac arrest, hypotension |
What type of drugs affect carbohydrate and lipid metabolism? | Beta-adrenergic blocking drugs. |
How are side effects of beta blockers relate to diabetics? | Beta-blockers may affect insulin and glucose levels because it affects carbohydrate metabolism. When carb metabolism is affected the glucose production is reduced, therefore less glucose is in the blood stream. |
MOA the beta blockers drugs? | bind to beta-adrenergic recptors found in smooth and cardiac muscle membranes and compete with EPI and NE for binding to beta-adrenergic receptors. |
MOA alpha blockers | compete with NE for binding to the alpha-adrenergic receptors. alpha-adrenergic receptoss are located on smooth muscle membranes (blood vessels) it blocks NE. |
MOA of sympatholytics | block the actions of the SNS, EPI and NE |
sympatholytics are classified as | either alpha-adrenergic blockign or beta-adrenergic blocking drugs. |
Dopamine | affects movement (motor), decision making, cardiovascular system (boots heart rate) |
When levels of dopamine are low | Parkinson's and depression |
When dopamine levels are high | mania, schizophrenia |
Serotonin | affects sleep, arousal, libido, appetite, mood, judgment, anger, |
when serotonin levels are high | sever anxiety |
when serotonin levels are low | depression, |
MOA of paraympathomimetic | cholinergic drug that mimics stimulation of PNS, acts like ACH. causes diarrhea |
MOA parasympatholytic | anticholinergic drug that decreases activity of PNS; blocks Ach, causes constipation |
MOA of anticholinergic | inhibits the activity of PNS; does not affect SNS directly. |
What neurotransmitters cause psychosis or schizophrenia when they are high? | NE, Epi, dopamine |
to increase urination, what meds would be Rx | the best would be parasympathomimetic; cholinergic, sympatholytic |
5 organs where smooth muscle is found | bladder, lungs, uterus, intestine, heart |
to increase BP what meds would be Rx? | best Alpha adronergic drug; norepinephrine, bet, sympathomimetic, anticholinegic, parasympatholyic. |
Why would an alpha blockers be administered? | to lower BP without affecting heart directly. |
the difference between cholinergic and anticholinergic | cholinergics activates the PNS, anticholinergic inhibits the PNS. |
Cholinergic overdose | sweating, ^urination and frequency, bradycarida, pupil construction |