Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Pharm Ch. 45

Antineoplastic

QuestionAnswer
What is antineoplastic mean? Against new tissue growth like cancers
Why do cancer cells grow uncontrollably? 1. they do not have growth control mechanisms 2. Do not have positive physiologic fx
What is a cancerous primary legion? Original site of growth
What is metastasis? Uncontrolled cell growth, secondary lesion in new, remote part of body
What is neoplasm? Mass of new cells, tumor
What two types of tumors? benign, malignant
What are three types of cancer? 1.Carcinomas- arise from epithelial cells "epi car" 2.Sarcomas- from connective tissue ex: 3.Kaposi's sarcoma-Lymphomas/Leukemias- circulating tumors or hematologic malignancies
What are paraneoplastic syndromes? Alongside with cancer cachexia- most common, fatigue, fever, wt loss
Chemotherapy is subdivided in two groups 1.cell cycle-nonspecific (CCNS) 2.cell cycle-specific (CCS)
How do CCS-cell cycle specific drugs work on cancer? Cytotoxic- hurt cell at certain phase
What is important to know about chemotherapy? Narrow therapeutic window combo better drug resistance adverse effect dose limiting adverse effects
Which non cancerous cells do chemotherapy effect the most? Rapid growing like hair follicles, GI tract, bone marrow
Name 5 types of cancer tumors that cell cycle specific drugs attack antimetabolites mitotic inhibitors alkaloid topoisomerase 2 inhibitors Topoisomerase I inhibitor Antineoplastic enzymes
How do antimetabolites work 1.falsely substituting for purines, pyrimidines, or folic aci 2.inhibiting critical enzymes involved in the synthesis or function of these compounds
what is example of antimetabolite 1.Folate Antagonists(DNA only) 2.Purine Antagonists 3.Pyrimidine Antagonists All effect DNA and RNA
Antimetabolite Adverse Effects Tumor Lysis Syndrome-includes hyperphosphatemia, hyperlalemia, hypoclcemia, hyperuricemia
Antineoplastic Toxicity Neurologic, Cardiovascular, Pulmonary, Hepatobiliary, GI, Genitourinary, Dermatologic, Ocular, Otic, Metabolic
What do Mitotic Inhibitors Do? Work before/during Mitosis, CCS
What natural plants are mitotic inhibitors derived from? Periwinkle, Yew, Mayapple(Mandrake)
Mitotic Inhibitor & Etoposide Extravasation Antidote Hyaluronidase
Antimetabolites drugs Folate -methotrexate Purine - Cladribine, Fludarabine Pyrimidine-Capecitabine, Fluorouracil, Gemcitabine, Cytarabine
Mitotic Inhibitor Drugs Etoposide, Paclitaxel, Vincristine
What do Topisomerace 2 inhibitor do? CCS, hurt DNA S phase
Topisomerace 2 inhibitor Adverce Effects Bone Marrow Suppression Irinotecan -odd effect -Cholinergic Diarrhea (delayed, 2-10 days later)
Topisomerace 2 inhibitor Drugs Irinotecan, Topotecan
Created by: mary_ray
Popular Pharmacology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards