Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Pharm Ch. 45


What is antineoplastic mean? Against new tissue growth like cancers
Why do cancer cells grow uncontrollably? 1. they do not have growth control mechanisms 2. Do not have positive physiologic fx
What is a cancerous primary legion? Original site of growth
What is metastasis? Uncontrolled cell growth, secondary lesion in new, remote part of body
What is neoplasm? Mass of new cells, tumor
What two types of tumors? benign, malignant
What are three types of cancer? 1.Carcinomas- arise from epithelial cells "epi car" 2.Sarcomas- from connective tissue ex: 3.Kaposi's sarcoma-Lymphomas/Leukemias- circulating tumors or hematologic malignancies
What are paraneoplastic syndromes? Alongside with cancer cachexia- most common, fatigue, fever, wt loss
Chemotherapy is subdivided in two groups 1.cell cycle-nonspecific (CCNS) 2.cell cycle-specific (CCS)
How do CCS-cell cycle specific drugs work on cancer? Cytotoxic- hurt cell at certain phase
What is important to know about chemotherapy? Narrow therapeutic window combo better drug resistance adverse effect dose limiting adverse effects
Which non cancerous cells do chemotherapy effect the most? Rapid growing like hair follicles, GI tract, bone marrow
Name 5 types of cancer tumors that cell cycle specific drugs attack antimetabolites mitotic inhibitors alkaloid topoisomerase 2 inhibitors Topoisomerase I inhibitor Antineoplastic enzymes
How do antimetabolites work 1.falsely substituting for purines, pyrimidines, or folic aci 2.inhibiting critical enzymes involved in the synthesis or function of these compounds
what is example of antimetabolite 1.Folate Antagonists(DNA only) 2.Purine Antagonists 3.Pyrimidine Antagonists All effect DNA and RNA
Antimetabolite Adverse Effects Tumor Lysis Syndrome-includes hyperphosphatemia, hyperlalemia, hypoclcemia, hyperuricemia
Antineoplastic Toxicity Neurologic, Cardiovascular, Pulmonary, Hepatobiliary, GI, Genitourinary, Dermatologic, Ocular, Otic, Metabolic
What do Mitotic Inhibitors Do? Work before/during Mitosis, CCS
What natural plants are mitotic inhibitors derived from? Periwinkle, Yew, Mayapple(Mandrake)
Mitotic Inhibitor & Etoposide Extravasation Antidote Hyaluronidase
Antimetabolites drugs Folate -methotrexate Purine - Cladribine, Fludarabine Pyrimidine-Capecitabine, Fluorouracil, Gemcitabine, Cytarabine
Mitotic Inhibitor Drugs Etoposide, Paclitaxel, Vincristine
What do Topisomerace 2 inhibitor do? CCS, hurt DNA S phase
Topisomerace 2 inhibitor Adverce Effects Bone Marrow Suppression Irinotecan -odd effect -Cholinergic Diarrhea (delayed, 2-10 days later)
Topisomerace 2 inhibitor Drugs Irinotecan, Topotecan
Created by: mary_ray