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Pharm Ch. 44
Antiinflammatory and Antigout
Question | Answer |
---|---|
What is inflammation? | A localized protective response stimulation by injury to tissues that serve to destroy, dilute, or wall off both the injurious agent and the injured tissue |
What is gout? | Hyperuricemia, the arthritis caused by tissue buildup of uric acid crystals |
What properties do NSAIDs have? | Analgesic, antiinflammaroty, antirheumatic, and antipyretic(fever) |
Name the 5 cardinal signs of inflammatin | 1.erthema(redness) 2.edema(swelling) 3.heat(fever)4.pain 5.loss of function |
Prostaglandins (Prostaglandin Pathway) | vasodilation, capillary permeability, pain, fever |
COX (cyclo-oxygenase) | enzyme that converts arachidonic acid into prostaglandins |
Name the 5 NSAID groups | 1.Salicylates 2.Acetic Acid Derivatives 3.COX 2-inhiitors 4.Enolic Acid Derivatives 5.Propionic Acid Derivatives |
Salicylates Drugs | 1.Aspirin 2.Diflunisal 3.Salsalate 4.Choline Salicylate |
Salicylates Actions | Antiinflammatory, antiplatelet, antipyretic |
NSAIDs Indications | Acute Gout, Acute gout arthritis, Ankylosing Spondyilitis, Bursitis, Fever, Rheumatoid Arthritis, Mild to Moderate pain, |
NSAID Adverse Effects and Drugs that help | CV-noncardiogenic pulmonay edema, GI-indigestion, GI bleeding-dyspepsia Mucosal lesions misoprostol(Cytotec)- reduce effects, induce labor |
NSAID Conteraindications | Rhinitis, Vit K deficiency, Peptic ulcer, Aspirin Allergy |
Salicylism | Salicylate toxicity Sx - tinnitus, ototoxicity, nausea, vomiting Mild-Stop Treatment, Severe - Dialysis |
Salicylate Conterindication | Children with flulike Sx- associated with Reye's Syndrome, encephalopathy, liver shutdown |
Name some Acetic Acids | Indocin, Toradol, Voltaren, Clinoril, tolectin, lodine, ponstel |
Name COX-2 inhibitor | Celebrex Used for arthritis, dysmenorrhea(painful period) |
Name Enolic Acid Derivatives | Piroxicam(Feldene), Meloxican(Mobic), Namumetone(Relafen) |
Name Propionic Acids | Nalfon, Ansaid, Motrin, Advil, Naprosyn,Aleve, Daypro |
Antigout Drugs | Allpurinol-prevent uric acid production Colchicine-reduce inflammation Probenecid-incr excretion of uric acid in urine |
Allopurinol Skin Adverse Effects | Exfoliative dermatitis, Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis |
Nursing Implication | Assess for Contraindications, Preform Laboratory Test, Medication history, Take with milk or antacid, therapeutic affects 3-4 weeks, Monitor therapeutic effects, |