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Pharm Ch. 44

Antiinflammatory and Antigout

What is inflammation? A localized protective response stimulation by injury to tissues that serve to destroy, dilute, or wall off both the injurious agent and the injured tissue
What is gout? Hyperuricemia, the arthritis caused by tissue buildup of uric acid crystals
What properties do NSAIDs have? Analgesic, antiinflammaroty, antirheumatic, and antipyretic(fever)
Name the 5 cardinal signs of inflammatin 1.erthema(redness) 2.edema(swelling) 3.heat(fever)4.pain 5.loss of function
Prostaglandins (Prostaglandin Pathway) vasodilation, capillary permeability, pain, fever
COX (cyclo-oxygenase) enzyme that converts arachidonic acid into prostaglandins
Name the 5 NSAID groups 1.Salicylates 2.Acetic Acid Derivatives 3.COX 2-inhiitors 4.Enolic Acid Derivatives 5.Propionic Acid Derivatives
Salicylates Drugs 1.Aspirin 2.Diflunisal 3.Salsalate 4.Choline Salicylate
Salicylates Actions Antiinflammatory, antiplatelet, antipyretic
NSAIDs Indications Acute Gout, Acute gout arthritis, Ankylosing Spondyilitis, Bursitis, Fever, Rheumatoid Arthritis, Mild to Moderate pain,
NSAID Adverse Effects and Drugs that help CV-noncardiogenic pulmonay edema, GI-indigestion, GI bleeding-dyspepsia Mucosal lesions misoprostol(Cytotec)- reduce effects, induce labor
NSAID Conteraindications Rhinitis, Vit K deficiency, Peptic ulcer, Aspirin Allergy
Salicylism Salicylate toxicity Sx - tinnitus, ototoxicity, nausea, vomiting Mild-Stop Treatment, Severe - Dialysis
Salicylate Conterindication Children with flulike Sx- associated with Reye's Syndrome, encephalopathy, liver shutdown
Name some Acetic Acids Indocin, Toradol, Voltaren, Clinoril, tolectin, lodine, ponstel
Name COX-2 inhibitor Celebrex Used for arthritis, dysmenorrhea(painful period)
Name Enolic Acid Derivatives Piroxicam(Feldene), Meloxican(Mobic), Namumetone(Relafen)
Name Propionic Acids Nalfon, Ansaid, Motrin, Advil, Naprosyn,Aleve, Daypro
Antigout Drugs Allpurinol-prevent uric acid production Colchicine-reduce inflammation Probenecid-incr excretion of uric acid in urine
Allopurinol Skin Adverse Effects Exfoliative dermatitis, Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis
Nursing Implication Assess for Contraindications, Preform Laboratory Test, Medication history, Take with milk or antacid, therapeutic affects 3-4 weeks, Monitor therapeutic effects,
Created by: mary_ray